Tekirdağ Namık Kemal University, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey.
Ödemiş State Hospital, Department of Cardiology - İzmir, Turkey.
Rev Assoc Med Bras (1992). 2023 Oct 9;69(11):e20230518. doi: 10.1590/1806-9282.20230518. eCollection 2023.
In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.
Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery≥23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained.
There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26-134) and group 2=156 (73-293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3-30.2) and group 2=3.2 (2.1-32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56-11) and group 2=3.4 (0.64-5.75); p=0.017] was lower in group 2.
We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.
在本研究中，我们旨在寻找非 ST 段抬高型心肌梗死患者中简单且有用的生物标志物，以预测冠状动脉严重程度。
本研究纳入了 2022 年 5 月至 2022 年 12 月期间根据欧洲心脏病学会指南诊断为非 ST 段抬高型心肌梗死的患者。计算 Synergy between PCI with Taxus and Cardiac Surgery 评分以确定冠状动脉疾病的严重程度。根据 Synergy between PCI with Taxus and Cardiac Surgery 评分≥23 和 Synergy between PCI with Taxus and Cardiac Surgery<23 将这些患者分为两组。根据当前指南对诊断为非 ST 段抬高型心肌梗死的患者进行冠状动脉造影前的血液检查，研究血小板与淋巴细胞比值和中性粒细胞与淋巴细胞比值等生化标志物。比较两组患者的数据。
第 1 组有 281 例患者，第 2 组有 67 例患者。两组患者在年龄和性别等人口统计学数据方面无显著差异。血小板与淋巴细胞比值[第 1 组=125（26-134）和第 2 组=156（73-293）；p=0.001]和中性粒细胞与淋巴细胞比值[第 1 组=2.71（1.3-30.2）和第 2 组=3.2（2.1-32.1）；p=0.002]在 Synergy between PCI with Taxus and Cardiac Surgery 评分<23 的患者组中较高，而淋巴细胞与单核细胞比值[第 1 组=3.6（0.56-11）和第 2 组=3.4（0.64-5.75）；p=0.017]在第 2 组中较低。
我们观察到升高的血小板与淋巴细胞比值和中性粒细胞与淋巴细胞比值与冠状动脉严重程度相关。在血小板与淋巴细胞比值和中性粒细胞与淋巴细胞比值较高的患者中，多血管病变和慢性完全闭塞的发生率较高。
