Yaman Reena, DiCaudo David J, Sokumbi Olayemi, Pham Michael M, Aslam Fawad, Griffing W Leroy, Sullivan Megan M
Department of Rheumatology, Mayo Clinic, Jacksonville, FL 32224, USA.
Departments of Dermatology, Laboratory Medicine & Pathology, Mayo Clinic, Scottsdale, AZ 85259, USA.
J Clin Med. 2025 Jul 12;14(14):4940. doi: 10.3390/jcm14144940.
Rheumatoid arthritis is a relatively common rheumatic disease that can present with inflammatory arthritis and subcutaneous nodules. Multicentric reticulohistiocytosis and fibroblastic rheumatism are rarer entities that also present with these features. Two cases, one of each of fibroblastic rheumatism and multicentric reticulohistiocytosis, are described highlighting characteristic clinical, radiographic, and histologic findings. A narrative review of the literature on these rarer conditions, compared with rheumatoid arthritis, is provided with a focus on articular and cutaneous findings, available information on disease presentations, and key contrasting features that can aid in diagnosis. Radiographic erosion distribution and joint space narrowing, clinical nodule distribution and characteristics, and nodule histology can differ between these diseases. Multicentric reticulohistiocytosis and fibroblastic rheumatism should be considered in the evaluation of seronegative rheumatoid arthritis, especially in cases that do not respond predictably to standard therapies, and cutaneous nodule biopsy can aid in differentiating these three conditions.
类风湿关节炎是一种相对常见的风湿性疾病，可表现为炎症性关节炎和皮下结节。多中心网状组织细胞增多症和成纤维细胞性风湿症是较罕见的疾病，也有这些表现。本文描述了两例病例，分别为成纤维细胞性风湿症和多中心网状组织细胞增多症，突出了其特征性的临床、影像学和组织学表现。本文对这些较罕见疾病的文献进行了叙述性综述，并与类风湿关节炎进行了比较，重点关注关节和皮肤表现、疾病表现的现有信息以及有助于诊断的关键对比特征。这些疾病在影像学侵蚀分布和关节间隙变窄、临床结节分布和特征以及结节组织学方面可能存在差异。在评估血清阴性类风湿关节炎时，应考虑多中心网状组织细胞增多症和成纤维细胞性风湿症，尤其是对标准治疗无预期反应的病例，皮肤结节活检有助于区分这三种疾病。
