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跨越避孕、妊娠和母乳喂养:心肌病女性的复杂历程

Sailing Across Contraception, Pregnancy, and Breastfeeding: The Complex Journey of Women with Cardiomyopathies.

作者信息

Carella Maria Cristina, Santobuono Vincenzo Ezio, Grosso Francesca Maria, Dicorato Marco Maria, Basile Paolo, Dentamaro Ilaria, Naccarati Maria Ludovica, Santoro Daniela, Monitillo Francesco, Valecce Rosanna, Ruggieri Roberta, Agea Aldo, Pepe Martino, Pontone Gianluca, Vimercati Antonella, Cicinelli Ettore, Laforgia Nicola, Resta Nicoletta, Guaricci Andrea Igoren, Ciccone Marco Matteo, Forleo Cinzia

机构信息

Cardiology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari "Aldo Moro", University Hospital Consortium Polyclinic of Bari, 70124 Bari, Italy.

Internal Medicine Section, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", University Hospital Consortium Polyclinic of Bari, 70124 Bari, Italy.

出版信息

J Clin Med. 2025 Jul 14;14(14):4977. doi: 10.3390/jcm14144977.

Abstract

Gender-specific cardiology has gained increasing recognition in recent years, emphasizing the need for tailored management strategies for women with cardiovascular disease. Among these, cardiomyopathies-dilated, arrhythmogenic, hypertrophic, and restrictive-pose unique challenges throughout a woman's reproductive life, affecting contraception choices, pregnancy outcomes, and breastfeeding feasibility. Despite significant advances in cardiovascular care, there is still limited guidance on balancing maternal safety and neonatal well-being in this complex setting. This review provides a comprehensive overview of the current evidence on reproductive counseling, pregnancy management, and postpartum considerations in women with cardiomyopathies. We discuss the cardiovascular risks associated with each cardiomyopathy subtype during pregnancy, highlighting risk stratification tools and emerging therapeutic strategies. Additionally, we address the safety and implications of breastfeeding, an often overlooked but increasingly relevant aspect of postpartum care. A multidisciplinary approach involving cardiologists, gynecologists, obstetricians, and anesthesiologists is crucial to optimizing maternal and fetal outcomes. Improved risk assessment, tailored patient counseling, and careful management strategies are essential to ensuring safer reproductive choices for women with cardiomyopathy. From now on, greater attention is expected to be given to bridging existing knowledge gaps, promoting a more personalized and evidence-based approach to managing these patients throughout different stages of reproductive life.

摘要

近年来,针对性别差异的心脏病学越来越受到认可,强调需要为患有心血管疾病的女性制定量身定制的管理策略。其中,扩张型、致心律失常型、肥厚型和限制型心肌病在女性的整个生殖生活中带来了独特的挑战,影响避孕选择、妊娠结局和母乳喂养的可行性。尽管心血管护理取得了重大进展,但在这种复杂情况下,关于平衡孕产妇安全和新生儿健康的指导仍然有限。本综述全面概述了目前关于心肌病女性生殖咨询、妊娠管理和产后注意事项的证据。我们讨论了妊娠期间与每种心肌病亚型相关的心血管风险,重点介绍了风险分层工具和新兴治疗策略。此外,我们还探讨了母乳喂养的安全性及其影响,母乳喂养是产后护理中一个经常被忽视但越来越重要的方面。心脏病专家、妇科医生、产科医生和麻醉医生参与的多学科方法对于优化母婴结局至关重要。改进风险评估、量身定制患者咨询和谨慎的管理策略对于确保心肌病女性做出更安全的生殖选择至关重要。从现在开始,预计将更加关注弥合现有知识差距,在女性生殖生活的不同阶段推广更个性化、基于证据的方法来管理这些患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d02d/12295082/35595885ad27/jcm-14-04977-g001.jpg

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