Lindgren L, Saarnivaara L
Acta Anaesthesiol Scand. 1985 Oct;29(7):679-82. doi: 10.1111/j.1399-6576.1985.tb02280.x.
The anxiety and pain-relieving effect of paracetamol 10 mg/kg or a combination of aminophenazone 4 mg/kg and diazepam 0.2 mg/kg suppositories was studied in 82 children after tonsillectomy in a double-blind study. Both suppositories were studied after halothane or enflurane anaesthesia. At 30 min after administration of coded suppositories, 88-90% of the children in various groups needed extra analgesics, and received pethidine 0.5 mg/kg i.v. Thereafter, the anxiety and pain relief was satisfactory in all groups. There was no significant difference between the effects caused by the drugs. No bleeding occurred from the operation site in any of the study groups. The results suggest that both paracetamol and a combination of aminophenazone and diazepam in the doses used here were weak analgesics for throat pain after tonsillectomy in children during the early postoperative period.
在一项双盲研究中,对82名扁桃体切除术后的儿童,研究了10毫克/千克对乙酰氨基酚或4毫克/千克氨基比林与0.2毫克/千克地西泮栓剂组合的抗焦虑和止痛效果。两种栓剂均在氟烷或恩氟烷麻醉后进行研究。在给予编码栓剂30分钟后,各组中88 - 90%的儿童需要额外的镇痛药,并静脉注射了0.5毫克/千克哌替啶。此后,所有组的焦虑和疼痛缓解情况均令人满意。药物所产生的效果之间无显著差异。任何研究组的手术部位均未发生出血。结果表明,此处所用剂量的对乙酰氨基酚以及氨基比林与地西泮的组合,对儿童扁桃体切除术后早期的咽痛而言都是弱镇痛药。