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2002年至2022年韩国自发性蛛网膜下腔出血的发病率、治疗方法及治疗结果趋势

Trends in Incidences, Treatments and Outcomes of Spontaneous Subarachnoid Hemorrhage in Korea Between 2002 and 2022.

作者信息

Park Jinju, Baek Ji Yoon, Lee Sung Ho, Jung Keun-Hwa, Lee Hae-Young, Shin Aesun, Cho Won-Sang

机构信息

National Heart and Stroke Center, Seoul National University Hospital, Seoul, Korea.

Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, Korea.

出版信息

J Korean Med Sci. 2025 Jul 28;40(29):e171. doi: 10.3346/jkms.2025.40.e171.

Abstract

BACKGROUND

Access to equitable care for severely emergent diseases serves as a key indicator for evaluating the performance of a country's health care system. The aim of this study was to examine trends in the incidence, treatment and outcomes of patients with spontaneous subarachnoid hemorrhage (SAH) using Korean national claims data.

METHODS

A retrospective analysis was conducted on a cohort of inpatients with spontaneous SAH from 2002 to 2022, utilizing data from the Korean National Health Insurance Service. The primary outcomes assessed were fatalities within 30 and 90 days from the index date of hospitalization.

RESULTS

While the crude incidence rate has remained constant, the age-standardized incidence rate (ASR) has decreased from 22.0 per 100,000 in 2002 to 12.5 per 100,000 in 2022. The regions with the highest incidence rates were Gyeonggi (29,833 cases, 21.0%) and Seoul (26,484, 18.7%). In 2002, 59.6% of all patients received major treatments within 48 hours of admission, with a distribution of 68.4% in tertiary hospitals and 30.7% in secondary hospitals. By 2022, the proportion of patients receiving major treatment had increased to 71.9%, with 42.3% in tertiary hospitals and 57.5% in secondary hospitals. Endovascular coiling surpassed surgical clipping as the predominant treatment modality between 2013 and 2014. On average, 70.1% of treated patients received care within their area of residence, with the highest rates in Daegu (92.9%), Gwangju (91.4%) and Busan (90.1%) and the lowest in Jeonnam (14.2%). From 2002 to 2019, the 30-day and 90-day fatality rates declined from 21.2% to 19.2% and from 24.4% to 21.3%, respectively, whereas these rates gradually increased after 2020.

CONCLUSION

The total number of patients with spontaneous SAH remained relatively constant, whereas both the ASR and overall crude fatality rate declined. A national shift in treatment modalities was observed, with coiling surpassing clipping and admissions to secondary hospitals exceeding those to tertiary hospitals. Regional disparities in health care utilization were identified, highlighting the need for a locally accountable health care system in health care policy.

摘要

背景

获得针对严重急症的公平医疗服务是评估一个国家医疗体系绩效的关键指标。本研究的目的是利用韩国全国医保数据,研究自发性蛛网膜下腔出血(SAH)患者的发病率、治疗情况及预后趋势。

方法

对2002年至2022年期间自发性SAH住院患者队列进行回顾性分析,数据来自韩国国民健康保险服务机构。评估的主要结局是自住院索引日期起30天和90天内的死亡情况。

结果

虽然粗发病率保持不变,但年龄标准化发病率(ASR)从2002年的每10万人22.0例降至2022年的每10万人12.5例。发病率最高的地区是京畿道(29,833例,21.0%)和首尔(26,484例,18.7%)。2002年,所有患者中有59.6%在入院后48小时内接受了主要治疗,其中三级医院的比例为68.4%,二级医院为30.7%。到2022年,接受主要治疗的患者比例增至71.9%,其中三级医院为42.3%,二级医院为57.5%。2013年至2014年期间,血管内栓塞术超过手术夹闭术成为主要治疗方式。平均而言,70.1%的接受治疗的患者在其居住地区接受治疗,大邱(92.9%)、光州(91.4%)和釜山(90.1%)的比例最高,全南(14.2%)最低。从2002年到2019年,30天和90天死亡率分别从21.2%降至19.2%和从24.4%降至21.3%,而2020年后这些比率逐渐上升。

结论

自发性SAH患者总数保持相对稳定,而ASR和总体粗死亡率均有所下降。观察到治疗方式的全国性转变,栓塞术超过夹闭术,且二级医院的入院人数超过三级医院。确定了医疗服务利用方面的地区差异,凸显了在医疗政策中建立地方问责制医疗体系的必要性。

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