Squire C R, Gimlette T M
J Clin Pathol. 1977 Jul;30(7):635-7. doi: 10.1136/jcp.30.7.635.
The response to an intravenous dose of 200 microng of thyrotrophin releasing hormone (TRH) has been studied by estimating, by radioimmunoassay, baseline levels followed by further estimations of thyroid stimulating hormone (TSH) 20 minutes after the injection and triiodothyronine (T3) three hours after the injection in 112 patients referred for routine thyroid assessment. Comparison of diagnostic accuracy of the response to TRH gave similar results with both procedures but slightly better overall accuracy for the response measured by TSH assay. However, estimation of baseline T3 is a valuable test for hyperthyroidism, in contrast to baseline TSH, and combined with the estimation of T3 three hours after TRH injection provides an accurate additional test in borderline cases.
通过放射免疫测定法对112名因常规甲状腺评估前来就诊的患者进行研究，先测定基线水平，然后在静脉注射200微克促甲状腺激素释放激素（TRH）后20分钟进一步测定促甲状腺激素（TSH），并在注射后三小时测定三碘甲状腺原氨酸（T3），以此来研究对静脉注射TRH的反应。对TRH反应的诊断准确性比较表明，两种检测方法的结果相似，但TSH检测法测得的反应总体准确性略高。然而，与基线TSH相比，基线T3的测定对甲状腺功能亢进症是一项有价值的检测，并且结合TRH注射后三小时T3的测定，可为临界病例提供一项准确的附加检测。
