Sun Hongli, Lu Yapeng, Wang Yingbin
Department of Anesthesiology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou, Gansu Province, 730030, China.
JPRAS Open. 2025 Jul 5;45:311-316. doi: 10.1016/j.jpra.2025.06.022. eCollection 2025 Sep.
In current pain management practices, multimodal analgesia strategies centered on regional nerve blocks, combined with low-dose opioids and adequate nonsteroidal anti-inflammatory drugs, are considered the standard approach. However, the short-lived effectiveness of conventional local anesthetics leads to inadequate postoperative pain management, which substantially diminishes patient comfort and satisfaction during recovery periods. Prolonging the duration of local anesthetics has become a core focus of regional anesthesia research, with liposomal bupivacaine gaining attention due to its ultra-long-acting properties. This article aims to systematically explore the mechanism of action, safety, potential adverse reactions, and clinical applications of liposomal bupivacaine in nerve blocks and surgical procedures, providing a scientific basis for optimizing clinical analgesia strategies.
在当前的疼痛管理实践中，以区域神经阻滞为核心，联合低剂量阿片类药物和适量非甾体类抗炎药的多模式镇痛策略被视为标准方法。然而，传统局部麻醉药的短效性导致术后疼痛管理不足，这在很大程度上降低了患者恢复期的舒适度和满意度。延长局部麻醉药的作用时间已成为区域麻醉研究的核心焦点，脂质体布比卡因因其超长时效特性而受到关注。本文旨在系统探讨脂质体布比卡因在神经阻滞和外科手术中的作用机制、安全性、潜在不良反应及临床应用，为优化临床镇痛策略提供科学依据。
