Kerff Fannie, Pasco Julie A, Williams Lana J, Jacka Felice N, Loughman Amy, Dawson Samantha L
Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.
Laboratory of Food Systems Biotechnology, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.
Depress Anxiety. 2025 Jul 21;2025:9961595. doi: 10.1155/da/9961595. eCollection 2025.
Systemic inflammation is associated with depression. Certain oral bacterial species contribute to inflammation; however their potential association with mental disorders remains unclear. This study investigated the associations between oral microbiota pathogens and depressive and anxiety symptoms. Data came from 436 men from the Geelong Osteoporosis Study. Oral microbiota was characterized using 16S rRNA sequencing, and an oral pathogen composite was created comprising , , , and species relative abundances. Binary variables were created representing elevated depressive and anxiety symptoms using the Hospital Anxiety and Depression Scale. Logistic regression was used to investigate associations between oral pathogens and elevated depressive/anxiety symptoms. Models were adjusted for confounders: age, socioeconomic status, diet, smoking, alcohol, exercise, obesity, and hypertension. We report a modest (nonsignificant) association between the pathogen composite and elevated depressive (OR 1.35 [95% CI 0.974, 1.87]) but not anxiety symptoms. Moreover, some of the comprising species were significantly associated with elevated depressive symptoms, including (1.61 [1.21, 2.13]). Our exploratory analyses revealed that several other taxa were significantly associated with depression and anxiety symptoms. The findings suggest that specific oral bacteria may contribute to symptoms of depression, warranting further research through larger and longitudinal investigations.
全身炎症与抑郁症有关。某些口腔细菌种类会导致炎症；然而，它们与精神障碍的潜在关联仍不清楚。本研究调查了口腔微生物病原体与抑郁和焦虑症状之间的关联。数据来自吉朗骨质疏松症研究中的436名男性。使用16S rRNA测序对口腔微生物群进行表征，并创建了一个口腔病原体组合，该组合包括 、 、 和 物种的相对丰度。使用医院焦虑和抑郁量表创建代表抑郁和焦虑症状加重的二元变量。采用逻辑回归分析口腔病原体与抑郁/焦虑症状加重之间的关联。模型对混杂因素进行了调整：年龄、社会经济地位、饮食、吸烟、饮酒、运动、肥胖和高血压。我们报告病原体组合与抑郁症状加重之间存在适度（无统计学意义）的关联（OR 1.35 [95% CI 0.974, 1.87]），但与焦虑症状无关。此外，组成该组合的一些物种与抑郁症状加重显著相关，包括 （1.61 [1.21, 2.13]）。我们的探索性分析表明，其他几个分类群与抑郁和焦虑症状显著相关。研究结果表明，特定的口腔细菌可能导致抑郁症状，需要通过更大规模的纵向研究进行进一步调查。
