Hiramatsu Y, Eguchi K, Sekiba K
Acta Med Okayama. 1985 Oct;39(5):339-46. doi: 10.18926/AMO/31524.
Polyamines have a close relationship with rapid cell proliferation. We measured polyamine levels in amniotic fluid, maternal plasma and urine during normal pregnancy. Plasma putrescine, spermidine and spermine gradually increased in the third trimester and reached the highest concentration at the end of pregnancy. There was a significant correlation between the level of these polyamines and the level of plasma estradiol and progesterone. In urine, putrescine and spermine increased with the progress of gestation and reached the highest level during the 8th to 10th months of gestation. In amniotic fluid, putrescine and spermidine concentrations were significantly high in the first trimester and decreased in the other trimesters, whereas spermine showed no significant change. Polyamine concentrations in maternal plasma and urine appear to reflect not only fetal metabolic changes but also the metabolic changes of the pregnant women, and to be influenced by several hormones which increase during pregnancy. Polyamines in amniotic fluid mainly reflect activated fetal metabolism and may be useful as biochemical indicators of fetal growth.
多胺与细胞快速增殖密切相关。我们检测了正常孕期羊水、母体血浆和尿液中的多胺水平。血浆腐胺、亚精胺和精胺在妊娠晚期逐渐升高，并在妊娠末期达到最高浓度。这些多胺水平与血浆雌二醇和孕酮水平之间存在显著相关性。在尿液中，腐胺和精胺随着孕周增加而升高，并在妊娠第8至10个月达到最高水平。在羊水中，腐胺和亚精胺浓度在孕早期显著升高，在其他孕期降低，而精胺无显著变化。母体血浆和尿液中的多胺浓度似乎不仅反映胎儿代谢变化，还反映孕妇的代谢变化，并受孕期升高的几种激素影响。羊水中的多胺主要反映胎儿代谢活跃，可能作为胎儿生长的生化指标。
