Cantu Jody C, Echchgadda Ibtissam, Butterworth Joseph W, Payne Jason A, Johnson Leland R, Freeman David A, Williams Weston C, Hoff Brad W, Thomas Robert J, Roach William P, Ibey Bennett L
General Dynamics Information Technology, JBSA Fort Sam Houston, Texas, USA.
Bioeffects Division, Human Effectiveness Directorate, 711th Human Performance Wing, Air Force Research Laboratory, JBSA Fort Sam Houston, Texas, USA.
Bioelectromagnetics. 2025 Sep;46(6):e70015. doi: 10.1002/bem.70015.
The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic had a tremendous impact on human life and global economics, motivating the invention of technology that can limit the spread of the virus from human to human in public areas. One candidate for such a purpose is radio frequency (RF) radiation, which was previously suggested to have a significant impact on viral integrity at exposure levels considered non-damaging to humans. However, these publications provided a limited explanation of the mechanism of action resulting in viral inactivation during RF exposure. One hypothesis was that structure resonance energy transfer (SRET) was occurring between the incident RF waves and the viral particle, which is highly dependent on the incident electric field strength. In this paper, we report exposures of bovine coronavirus (BCoV) to high peak power microwave (HPPM) pulses to validate the dependence of viral rupture on peak electric field as a critical parameter driving SRET. We tested 0.1-1.5 MW, 2 µs pulsed exposures of viral-containing buffer at 2.8, 5.6, 8.5, and 9.3 GHz up to 100,000 pulses and found no evidence of clinically significant E-field dependent decreases in viral infectivity. The findings reported in this manuscript do not support the hypothesis that SRET is a dominant mechanism behind RF-induced viral inactivation. Bioelectromagnetics. 00:00-00, 2025. © 2025 Published 2025. This article is a U.S. Government work and is in the public domain in the USA.
最近的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行对人类生活和全球经济产生了巨大影响，促使人们发明能够在公共场所限制病毒在人与人之间传播的技术。射频（RF）辐射就是实现这一目的的一个候选技术，此前有研究表明，在对人体无损害的暴露水平下，射频辐射对病毒完整性有显著影响。然而，这些出版物对射频暴露期间导致病毒失活的作用机制解释有限。一种假设是，入射射频波与病毒颗粒之间发生了结构共振能量转移（SRET），这高度依赖于入射电场强度。在本文中，我们报告了牛冠状病毒（BCoV）暴露于高峰值功率微波（HPPM）脉冲的情况，以验证病毒破裂对峰值电场的依赖性，峰值电场是驱动SRET的关键参数。我们在2.8、5.6、8.5和9.3 GHz频率下，对含有病毒的缓冲液进行了0.1 - 1.5 MW、2 µs的脉冲暴露，暴露次数高达100,000次，未发现病毒感染力出现与电场相关的具有临床意义的下降迹象。本手稿中报告的研究结果不支持SRET是射频诱导病毒失活背后的主要机制这一假设。生物电磁学。00:00 - 00，2025年。© 2025年出版。本文为美国政府作品，在美国属于公共领域。
