Zhang Chen, Ding Wen-Xing
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Division of Gastroenterology, Hepatology and Motility, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
J Cell Biol. 2025 Aug 4;224(8). doi: 10.1083/jcb.202506103. Epub 2025 Jul 29.
The mechanisms by which alcohol increases lipid droplet accumulation are still unclear. In this issue, Sen et al. (https://doi.org/10.1083/jcb.202408205) identify a new pathway through which chronic alcohol exposure promotes hepatic steatosis via a UBXD8-p97/VCP-HSD17β13 axis, which regulates lipid droplet homeostasis.
酒精增加脂滴积累的机制仍不清楚。在本期中,森等人(https://doi.org/10.1083/jcb.202408205)发现了一条新途径,慢性酒精暴露通过该途径经由UBXD8-p97/VCP-HSD17β13轴促进肝脂肪变性,该轴调节脂滴稳态。