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氯化三丁基锡对哈德氏（Haarder）肝脏的毒性反应：氧化应激、能量代谢功能障碍和细胞凋亡。

Toxicity Responses from Tributyltin Chloride on Haarder () Livers: Oxidative Stress, Energy Metabolism Dysfunction, and Apoptosis.

作者信息

Zhao Changsheng, Suo Anning, Ding Dewen, Song Wencheng

机构信息

Institute for the Control of Agrochemicals, Ministry of Agriculture and Rural Affairs, Beijing 100125, China.

Key Laboratory of Pesticide Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100125, China.

出版信息

Curr Issues Mol Biol. 2025 Jul 8;47(7):526. doi: 10.3390/cimb47070526.

DOI:10.3390/cimb47070526
PMID:40728995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12293897/
Abstract

In coastal waters, tributyltin chloride (TBTC), a persistent organic pollutant, is extensively present. It is uncertain, therefore, if exposure to TBTC can harm haarders and how. This study exposed the fish for 60 days in order to investigate the molecular mechanism of haarder following TBTC poisoning. Our findings demonstrated that growth indices dropped, liver tissue was damaged, and the liver's total tin concentration rose following TBTC exposure. Furthermore, we discovered that blood reactive oxygen species rose while total blood cell count decreased. As malondialdehyde levels rose, total antioxidant capacity and antioxidant enzyme activity (superoxide dismutase, catalase, and glutathione peroxidase) were markedly reduced. After being exposed to TBTC, liver cells displayed clear signs of apoptosis. Differentially expressed genes were primarily linked to oxidative stress, energy metabolism, and apoptosis, according to the transcriptome study of livers. Overall, the long-term stress of TBTC resulted in the antioxidant system being harmed, as well as serious malfunction of the energy metabolism and apoptotic response.

摘要

在沿海水域中，持久性有机污染物氯化三丁基锡（TBTC）广泛存在。因此，尚不确定接触TBTC是否会对鲽鱼造成危害以及如何造成危害。本研究将鱼暴露60天，以探究TBTC中毒后鲽鱼的分子机制。我们的研究结果表明，接触TBTC后，生长指标下降，肝脏组织受损，肝脏总锡浓度升高。此外，我们发现血液中的活性氧增加，而全血细胞计数减少。随着丙二醛水平升高，总抗氧化能力和抗氧化酶活性（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）显著降低。接触TBTC后，肝细胞出现明显的凋亡迹象。根据肝脏的转录组研究，差异表达基因主要与氧化应激、能量代谢和凋亡有关。总体而言，TBTC的长期应激导致抗氧化系统受损，以及能量代谢和凋亡反应严重失调。

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