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孕前父母人格障碍与围产期心理社会结局:一项基于人群的前瞻性研究。

Preconception parental personality disorder and psychosocial outcomes during the perinatal period: a prospective population-based study.

作者信息

Wilson Claire A, Husin Hanafi Mohamad, Dashti S Ghazaleh, Catalao Raquel, Borschmann Rohan, Brown Stephanie, Howard Louise M, Kerr Jessica A, Monk-Cunliffe Jonathan, Moran Paul, Patton George C, Olsson Craig A, Spry Elizabeth

机构信息

Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust, London, UK.

Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Australia.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2025 Jul 29. doi: 10.1007/s00127-025-02968-3.

Abstract

PURPOSE

Birthing individuals with personality disorder in young adulthood before pregnancy may be at increased risk of potentially modifiable adverse outcomes in the perinatal period that impact parental and child health. We aimed to investigate the perinatal psychosocial outcomes of preconception (prior to pregnancy) personality disorder.

METHODS

Prospective analysis of 398 birthing individuals with 609 infants from Victorian Intergenerational Health Cohort Study (VIHCS). Preconception personality disorder was measured using the Standardised Assessment of Personality (SAP) at age 24. A range of parental outcomes were assessed during pregnancy and at one year postpartum (age 28 to 37). Log-binomial generalised estimating equations were used to estimate univariable associations between preconception personality disorder and each perinatal outcome.

RESULTS

Individuals with preconception personality disorder (compared to those without) were approximately two times more likely to have antenatal anxiety symptoms (risk ratio (RR) 2.08, 95% confidence interval (CI) 1.19-3.65) and reduced social support (antenatal RR 2.01, 95% CI 0.98-4.13; postnatal RR 1.38, 95% CI 0.91-2.10). Weaker associations were also observed for experiencing stressful life events (RR 1.37, 95% CI 0.98-1.90) and, albeit with less certainty, for poorer partner relationship quality (RR 1.44, 95% CI 0.78-2.64) and depressive symptoms (antenatal RR 1.56, 95% CI 0.84-2.91; postnatal RR 1.44, 95% CI 0.73-2.83). Close to null associations were observed for parents' self-efficacy or perceived parent-infant bond.

CONCLUSION

The findings highlight a group who may be vulnerable to multiple adverse perinatal outcomes; those with personality disorder and their families may benefit from additional support both with pregnancy planning and into parenthood.

摘要

目的

年轻成年期患有个性障碍的生育个体在怀孕前可能面临围产期潜在可改变的不良结局风险增加,这些结局会影响父母和儿童健康。我们旨在调查孕前(怀孕前)个性障碍的围产期心理社会结局。

方法

对来自维多利亚代际健康队列研究(VIHCS)的398名生育个体及其609名婴儿进行前瞻性分析。在24岁时使用标准化人格评估(SAP)测量孕前个性障碍。在孕期和产后一年(28至37岁)评估一系列父母结局。使用对数二项式广义估计方程来估计孕前个性障碍与每个围产期结局之间的单变量关联。

结果

患有孕前个性障碍的个体(与未患有的个体相比)出现产前焦虑症状的可能性大约高出两倍(风险比(RR)2.08,95%置信区间(CI)1.19 - 3.65),并且社会支持减少(产前RR 2.01,95% CI 0.98 - 4.13;产后RR 1.38,95% CI 0.91 - 2.10)。在经历压力性生活事件方面也观察到较弱的关联(RR 1.37,95% CI 0.98 - 1.90),并且在伴侣关系质量较差(RR 1.44,95% CI 0.78 - 2.64)和抑郁症状方面(产前RR 1.56,95% CI 0.84 - 2.91;产后RR 1.44,95% CI 0.73 - 2.83),虽然确定性较低,但也有观察到关联。在父母的自我效能感或感知的亲子关系方面观察到几乎没有关联。

结论

研究结果突出了一组可能易受多种不良围产期结局影响的人群;患有个性障碍的个体及其家庭可能会从怀孕计划和为人父母过程中的额外支持中受益。

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