Nakhaei Ali, Afshari Sadaf, Omidkhoda Arezoo, Mohtashami Elmira, Vahedi Mohammad Mahdi, Ahmadi Seyed Sajad, Jalali Mahsa, Afshari Amir R
Student Research Committee, MMS.C., Islamic Azad University, Mashhad, Iran.
Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Med Oncol. 2025 Jul 29;42(9):391. doi: 10.1007/s12032-025-02959-z.
Cancer is a leading cause of mortality worldwide, triggering healthcare system challenges and emphasizing the need for targeted treatment methods. Traditional cancer treatments can be ineffective, have long response times, and cause significant side effects that lower patients' quality of life. Recently, attention has switched to natural compounds with anticancer properties. Carnosol, a phenolic diterpene found in rosemary and sage, is a promising alternative. Carnosol has diverse biological effects, including influencing cellular signaling pathways for proliferation, apoptosis, inflammation, and oxidative stress. Recent research has revealed its anticancer properties, preventing tumor growth and progression in breast, prostate, colorectal, and glioblastoma multiforme. Carnosol's potential as a multi-targeted therapeutic drug is supported by these findings, paving the way for its clinical usage in cancer treatment.
癌症是全球主要的死亡原因之一，引发了医疗保健系统的挑战，并凸显了针对性治疗方法的必要性。传统的癌症治疗方法可能无效，反应时间长，还会导致严重的副作用，降低患者的生活质量。最近，人们的注意力已转向具有抗癌特性的天然化合物。鼠尾草酸是一种在迷迭香和鼠尾草中发现的酚类二萜，是一种很有前景的替代品。鼠尾草酸具有多种生物学效应，包括影响细胞增殖、凋亡、炎症和氧化应激的信号通路。最近的研究揭示了其抗癌特性，可预防乳腺癌、前列腺癌、结直肠癌和多形性胶质母细胞瘤的肿瘤生长和进展。这些发现支持了鼠尾草酸作为一种多靶点治疗药物的潜力，为其在癌症治疗中的临床应用铺平了道路。
