Sann L, Leclercq M, Troncy J, Guillaumond M, Berland M, Coeur P
Am J Obstet Gynecol. 1985 Dec 1;153(7):771-4. doi: 10.1016/0002-9378(85)90343-6.
The serum concentration of phylloquinone (vitamin K1) was measured in 34 healthy mothers and in the arterial cord blood of their newborn infants. In addition, the activities of factor II and of factors VII plus X were determined simultaneously in 16 paired maternal and fetal bloods. The serum vitamin K1 concentration was similar to that of control subjects in 27 mothers: 9.03 +/- 4.9 micrograms/L (mean and SD), with a simultaneous concentration of 10.4 +/- 5.3 micrograms/L in cord blood. Six mothers exhibited high serum vitamin K1 concentrations from 40 to 240 micrograms/L (median, 82) and the concentration in cord blood ranged from 25 to 115 micrograms/L (median, 71). One mother had a normal concentration of vitamin K1: 9 micrograms/L while no vitamin K1 was detectable in the serum of her infant. The activity of factor II and factors VII plus X was 7% and 7%, respectively, in this infant and 100% in the mother. All other mothers showed normal factor II and factors VII plus X activity, while the median activity was 47% (28%-56%) for factor II and 65% (35%-100%) for factors VII plus X in cord blood. These data suggest that vitamin K1 can cross the placental barrier but not in every case. Therefore the systematic administration of vitamin K1 to the newborn infant seems to be required to prevent the occurrence of the hemorrhagic disease.
对34名健康母亲及其新生儿的动脉脐血中的叶绿醌（维生素K1）血清浓度进行了测定。此外，对16对母婴血液同时测定了凝血因子II以及凝血因子VII和X的活性。27名母亲的血清维生素K1浓度与对照组相似：9.03±4.9微克/升（均值和标准差），脐血中同时浓度为10.4±5.3微克/升。6名母亲的血清维生素K1浓度较高，为40至240微克/升（中位数，82），脐血浓度范围为25至115微克/升（中位数，71）。一名母亲的维生素K1浓度正常：9微克/升，而其婴儿血清中未检测到维生素K1。该婴儿的凝血因子II以及凝血因子VII和X的活性分别为7%，而母亲为100%。所有其他母亲的凝血因子II以及凝血因子VII和X活性均正常，而脐血中凝血因子II的中位数活性为47%（28%-56%），凝血因子VII和X为65%（35%-100%）。这些数据表明维生素K1可以穿过胎盘屏障，但并非在所有情况下都能穿过。因此，似乎需要对新生儿系统地给予维生素K1以预防出血性疾病的发生。
