植物来源的外泌体：跨界调控的纳米诱导剂

Plant-Derived Exosomes: Nano-Inducers of Cross-Kingdom Regulations.

作者信息

Rehman Touseef Ur, Li Huiliang, Martuscelli Maria, Aiello Francesca, Esposito Luigi, Ashraf Kamran, Guo Meijin, Mohsin Ali

机构信息

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Department of Bioscience and Food, Agricultural and Environmental Technology, University of Teramo, Via Balzarini 1, 64100 Teramo, Italy.

出版信息

Pharmaceuticals (Basel). 2025 Jul 4;18(7):1005. doi: 10.3390/ph18071005.

DOI:10.3390/ph18071005

PMID:40732294

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12299123/

Abstract

Exosomes are essential components produced by all cell types, originating from the endosomal pathway through the invagination of the cell membrane. Their unique physicochemical characteristics are crucial for various commercial applications. Typically, exosomes range in size from 50 to 200 nm. Exosomes derived from plant cells are larger than their animal cell counterparts and demonstrate a broader therapeutic potential. This review explores the promising research opportunities associated with plant-derived exosomes, summarizing studies on their biogenesis, characterization, isolation methods, and therapeutic applications. It also emphasizes the importance of targeted drug delivery and provides insights into engineering plant-derived exosomes with various drugs. Additionally, highlights of plant-derived exosomes as natural nano-inducers that facilitate inter-kingdom communication and cross-kingdom regulatory interactions are also elucidated herein. Henceforth, this study culminates in a multidimensional insight for innovative therapeutic strategies and biotechnological advancements in plant-derived exosome research.

摘要

外泌体是所有细胞类型产生的重要成分，通过细胞膜内陷起源于内体途径。它们独特的物理化学特性对于各种商业应用至关重要。通常，外泌体的大小在50到200纳米之间。植物细胞来源的外泌体比动物细胞来源的外泌体更大，并且具有更广泛的治疗潜力。本综述探讨了与植物来源外泌体相关的有前景的研究机会，总结了关于其生物发生、表征、分离方法和治疗应用的研究。它还强调了靶向药物递送的重要性，并提供了用各种药物工程化植物来源外泌体的见解。此外，本文还阐明了植物来源外泌体作为促进跨王国通讯和跨王国调节相互作用的天然纳米诱导剂的亮点。此后，本研究最终对植物来源外泌体研究中的创新治疗策略和生物技术进步进行了多维度洞察。