Scoppola Vittorio, Crudele Annalisa, Mosca Antonella, Panera Nadia, Camillo Chiara di, Bock Caterina, Raponi Massimiliano, Villani Alberto, Alisi Anna, Valentini Diletta
Research Unit of Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Hepatology and Liver Transplant Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Nutrients. 2025 Jul 16;17(14):2331. doi: 10.3390/nu17142331.
: We evaluated the efficacy of a good lifestyle intervention on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with Down syndrome (DS). : This retrospective longitudinal study included 31 children with Down syndrome (DS) who were affected by MASLD and attended nutritional counseling based on a nutritional approach (e.g., Mediterranean diet and antioxidant supplements), as well as physical exercise. Clinical parameters, markers of low-grade systemic inflammation, and hepatic steatosis, as assessed by ultrasound, were evaluated at baseline (T0) and after 6 months (T1). : Several anthropometric and biochemical parameters, including body mass index, waist circumference, diastolic and systolic blood pressure, aspartate aminotransferase, basal insulin, insulin resistance, pro-inflammatory interleukin-1β, and anti-inflammatory interleukin-10, showed significant improvement after 6 months of a nutritional approach. This study also found a regression of at least one grade of hepatic steatosis in a significant portion of patients, especially in those who received antioxidant supplements. : Our study further supports the hypothesis that a healthy lifestyle intervention, based on adherence to the Mediterranean diet, natural supplements with antioxidant properties, and regular physical activity, can be considered a safe therapeutic approach for reducing the risk and severity of MASLD in children with DS.
我们评估了良好生活方式干预对唐氏综合征（DS）患儿代谢功能障碍相关脂肪性肝病（MASLD）严重程度的疗效。这项回顾性纵向研究纳入了31名患有MASLD的唐氏综合征患儿，他们接受了基于营养方法（如地中海饮食和抗氧化补充剂）以及体育锻炼的营养咨询。在基线（T0）和6个月后（T1）评估了临床参数、低度全身炎症标志物以及通过超声评估的肝脂肪变性。包括体重指数、腰围、舒张压和收缩压、天冬氨酸转氨酶、基础胰岛素、胰岛素抵抗、促炎白细胞介素-1β和抗炎白细胞介素-10在内的多项人体测量和生化参数在采用营养方法6个月后显示出显著改善。本研究还发现，相当一部分患者的肝脂肪变性至少有一个等级的消退，尤其是那些服用抗氧化补充剂的患者。我们的研究进一步支持了这样一种假设，即基于坚持地中海饮食、具有抗氧化特性的天然补充剂和定期体育活动的健康生活方式干预可被视为降低DS患儿MASLD风险和严重程度的一种安全治疗方法。
