De Stefanis Daniela, Costelli Paola
Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Nutrients. 2025 Jul 16;17(14):2334. doi: 10.3390/nu17142334.
The advantages of extra virgin olive oil (EVOO) intake as part of a varied, healthy and balanced diet were demonstrated by many epidemiological studies. In particular, several components present in EVOO, such as tocopherols, carotenoids and phenolic compounds, play an important protective role in mitigating inflammatory diseases, atherosclerosis, neurodegenerative diseases and cancer. The protective effect exerted by EVOO was proposed to be accounted for by its antioxidant, anti-inflammatory or anti-proliferative properties. The present review will focus on the interactions among EVOO's components and pro-inflammatory cytokines, aiming to reveal the mechanisms potentially involved in the anticancer action of EVOO. Cancer patients very frequently develop a devastating syndrome known as cachexia, which negatively impinges on their outcome. The main features of cachexia include progressive body weight loss, fat and muscle wasting, and dysmetabolism, all of which partially result from the onset of systemic inflammation. In this regard, the possibility that EVOO could be beneficial to cancer patients by mitigating cachexia will be reviewed, focusing on the skeletal muscle.
许多流行病学研究表明，作为多样化、健康且均衡饮食的一部分，摄入特级初榨橄榄油（EVOO）具有诸多益处。特别是，EVOO中含有的几种成分，如生育酚、类胡萝卜素和酚类化合物，在减轻炎症性疾病、动脉粥样硬化、神经退行性疾病和癌症方面发挥着重要的保护作用。据推测，EVOO发挥的保护作用归因于其抗氧化、抗炎或抗增殖特性。本综述将聚焦于EVOO成分与促炎细胞因子之间的相互作用，旨在揭示EVOO抗癌作用可能涉及的机制。癌症患者经常会出现一种毁灭性的综合征，即恶病质，这会对他们的预后产生负面影响。恶病质的主要特征包括体重逐渐减轻、脂肪和肌肉消耗以及代谢紊乱，所有这些部分是由全身炎症的发作导致的。在这方面，将综述EVOO通过减轻恶病质对癌症患者有益的可能性，重点关注骨骼肌。
