Morvaridzadeh Mojgan, Alami Mehdi, Zoubdane Nada, Sidibé Hawa, Berrougui Hicham, Fülöp Tamàs, Nguyen Michel, Khalil Abdelouahed
Geriatrics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.
Department of Biology, Polydisciplinary Faculty, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco.
Antioxidants (Basel). 2025 Jul 16;14(7):867. doi: 10.3390/antiox14070867.
Cardiovascular disease (CVD), particularly atherosclerotic cardiovascular disease (ASCVD), is the leading cause of death worldwide, driven by factors like oxidative stress, inflammation, and lipid metabolism disorders. Although phenolic compounds such as Tyrosol (Tyr) and Hydroxytyrosol (HTyr) found in extra virgin olive oil (EVOO) have shown promising antioxidant and anti-inflammatory effects, their specific roles in modulating oxidative stress biomarkers and high-density lipoprotein (HDL) functionality in elderly populations, especially in those with prior myocardial infarction, are not fully understood. This study aimed to investigate the effects of EVOO phenolic compounds on oxidative stress biomarkers and HDL functionality, and related metabolic outcomes in both healthy and post-myocardial infarction (post-MI) elderly individuals. This pilot randomized clinical trial study included healthy and post-MI participants aged 65-85 years. Participants in each group were randomly assigned to consume 25 mL per day of one of three types of olive oils: high phenolic (HTyr/Tyr) extra virgin olive oil (HP-EVOO), extra virgin olive oil (EVOO), or refined olive oil (ROO) for a period of 26 weeks. Blood samples were collected at baseline and post-intervention to assess key biomarkers. Plasma levels of (poly)phenols, malondialdehyde (MDA), total antioxidant capacity (FRAP), lecithin-cholesterol acyltransferase activity (LCAT), and serum paraoxonase-1 (PON-1) activity were measured. A total of 34 individuals completed the study (mean age: 74 years). Baseline characteristics, including sex, age, body mass index (BMI), weight, blood pressure, and inflammatory markers like C-reactive protein (CRP) levels, did not differ significantly between the two groups. A significant increase in both FRAP levels and PON-1 activity was observed in post-MI participants following HP-EVOO consumption compared to baseline ( = 0.014). No significant changes were observed in MDA levels, LCAT activity, or plasma (poly)phenols. These results indicate that HP-EVOO may enhance antioxidant capacity, particularly FRAP and PON-1 activity, in elderly post-MI individuals. The observed differences between groups suggest that underlying cardiometabolic status may influence the response to olive oil phenolic compounds. Further studies are needed to explore the long-term cardiovascular effects.
心血管疾病（CVD），尤其是动脉粥样硬化性心血管疾病（ASCVD），是全球主要的死亡原因，由氧化应激、炎症和脂质代谢紊乱等因素驱动。尽管特级初榨橄榄油（EVOO）中发现的酚类化合物如酪醇（Tyr）和羟基酪醇（HTyr）已显示出有前景的抗氧化和抗炎作用，但其在调节老年人群氧化应激生物标志物和高密度脂蛋白（HDL）功能方面的具体作用，尤其是在那些有过心肌梗死的人群中，尚未完全了解。本研究旨在调查EVOO酚类化合物对健康和心肌梗死后（post-MI）老年个体氧化应激生物标志物、HDL功能及相关代谢结果的影响。这项初步随机临床试验研究纳入了65 - 85岁的健康和心肌梗死后参与者。每组参与者被随机分配每天食用25毫升三种类型橄榄油中的一种：高酚（HTyr/Tyr）特级初榨橄榄油（HP-EVOO）、特级初榨橄榄油（EVOO）或精炼橄榄油（ROO），为期26周。在基线和干预后采集血样以评估关键生物标志物。测量血浆中（多）酚、丙二醛（MDA）、总抗氧化能力（FRAP）、卵磷脂胆固醇酰基转移酶活性（LCAT）和血清对氧磷酶-1（PON-1）活性。共有34人完成了研究（平均年龄：74岁）。两组之间的基线特征，包括性别、年龄、体重指数（BMI）、体重、血压以及炎症标志物如C反应蛋白（CRP）水平，无显著差异。与基线相比，心肌梗死后参与者食用HP-EVOO后FRAP水平和PON-1活性均显著增加（ = 0.014）。MDA水平、LCAT活性或血浆（多）酚未观察到显著变化。这些结果表明，HP-EVOO可能增强心肌梗死后老年个体的抗氧化能力，尤其是FRAP和PON-1活性。组间观察到的差异表明潜在的心脏代谢状态可能影响对橄榄油酚类化合物的反应。需要进一步研究来探索其长期心血管效应。
