Fukushima M, Lupien J, Bray G A
Am J Physiol. 1985 Dec;249(6 Pt 2):R753-7. doi: 10.1152/ajpregu.1985.249.6.R753.
The food intake of sham-operated and adrenalectomized rats was measured in 12-h intervals with animals housed in either alternating periods of 12:12 light-dark or in continuous light. The food intake with alternating light and dark was unaffected by adrenalectomy. The maintenance of a constant infusion of corticosterone in adrenalectomized rats also did not disturb the pattern of food intake. In continuous light, food intake was not significantly different in each 12-h period of the daily cycle. Neither adrenalectomy nor the injection of corticosterone, 240 micrograms/day, altered the average 12-h food intake in rats in constant light. The weight of interscapular brown adipose was smaller in adrenalectomized animals, but the protein content was unaffected. Adrenalectomy significantly increased the specific binding of the purine nucleotide GDP to mitochondria from brown adipose tissue. This specific binding was restored to normal by either corticosterone infusion or injection. We conclude that light is the principal entrainer for the average food intake during 12-h periods and that within the framework of these experiments corticosterone plays an insignificant role in controlling food intake. However, adrenalectomy did significantly increase the purine nucleotide binding to mitochondria from brown adipose tissue.
对假手术组和肾上腺切除组大鼠的食物摄入量进行了测量，测量间隔为12小时，实验动物饲养在12:12明暗交替或持续光照环境中。在明暗交替环境下，肾上腺切除对食物摄入量没有影响。在肾上腺切除的大鼠中持续输注皮质酮也不会干扰食物摄入模式。在持续光照条件下，每日周期中每12小时的食物摄入量没有显著差异。肾上腺切除和每天注射240微克皮质酮均未改变持续光照条件下大鼠的平均12小时食物摄入量。肾上腺切除的动物肩胛间棕色脂肪的重量较小，但蛋白质含量未受影响。肾上腺切除显著增加了嘌呤核苷酸GDP与棕色脂肪组织线粒体的特异性结合。通过输注或注射皮质酮，这种特异性结合恢复到正常水平。我们得出结论，光照是12小时期间平均食物摄入的主要调节因素，在这些实验的框架内，皮质酮在控制食物摄入方面作用不大。然而，肾上腺切除确实显著增加了嘌呤核苷酸与棕色脂肪组织线粒体的结合。
