皮质酮、冷暴露及蔗糖过量喂养对肥胖型Zucker大鼠（fa/fa）棕色脂肪组织的影响

The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa).

作者信息

Holt S, York D A, Fitzsimons J T

出版信息

Biochem J. 1983 Jul 15;214(1):215-23. doi: 10.1042/bj2140215.

DOI:10.1042/bj2140215

PMID:6615467

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152229/

Abstract

GDP binding to brown-adipose-tissue mitochondria was decreased in obese Zucker rats. Adrenalectomy restored both GDP binding and serum tri-iodothyronine of obese rats to values observed in lean rats. The effects of adrenalectomy on GDP binding and serum tri-iodothyronine were reversed by corticosterone. Decreasing food intake had no effect on brown-adipose-tissue GDP binding in obese rats. Young (5-week-old) obese rats showed a normal increase in brown-adipose-tissue mitochondrial GDP binding after housing at 4 degrees C for 7 days, but this response was attenuated in 10-week-old obese rats. Overfeeding with sucrose increased brown-adipose-tissue thermogenesis in lean, but not in obese, rats. After adrenalectomy, overfeeding with sucrose enhanced brown-adipose-tissue mitochondrial GDP binding in obese rats.

摘要

在肥胖的Zucker大鼠中，GDP与棕色脂肪组织线粒体的结合减少。肾上腺切除术可使肥胖大鼠的GDP结合以及血清三碘甲状腺原氨酸恢复到瘦大鼠中的观察值。肾上腺切除术对GDP结合和血清三碘甲状腺原氨酸的影响可被皮质酮逆转。减少食物摄入量对肥胖大鼠棕色脂肪组织的GDP结合没有影响。年幼（5周龄）肥胖大鼠在4℃饲养7天后，棕色脂肪组织线粒体GDP结合正常增加，但这种反应在10周龄肥胖大鼠中减弱。用蔗糖过度喂养可增加瘦大鼠而非肥胖大鼠的棕色脂肪组织产热。肾上腺切除术后，用蔗糖过度喂养可增强肥胖大鼠棕色脂肪组织线粒体的GDP结合。