Sun Siyuan, Li Xinchun, Zhai Jianan, Lu Chenxu, Yu Weiru, Wu Wenhao, Chen Juan
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, China.
Nutrients. 2025 Jul 19;17(14):2367. doi: 10.3390/nu17142367.
RNA-binding proteins (RBPs) are critical regulators of post-transcriptional processes, playing essential roles in nutrient metabolism and metabolic homeostasis. This literature review explores how RBPs influence the metabolism of glucose, lipid, and amino acid metabolism by controlling processes like mRNA stability and translation regulation. The dysregulation of RBPs, including HuR, PTB, and YTHDF1, is linked to metabolic diseases such as obesity, diabetes, and non-alcoholic fatty liver disease. Advances in techniques like TREX technology and transcriptome analysis have deepened our understanding of RBP functions. Additionally, RBPs show promise as potential biomarkers and targets for new therapies. Future research directions in RBPs could focus on tissue-specific regulation and nutrient-RBP interactions. This could pave the way for more personalized treatments and improved metabolic health.
RNA结合蛋白（RBPs）是转录后过程的关键调节因子，在营养物质代谢和代谢稳态中发挥着重要作用。这篇文献综述探讨了RBPs如何通过控制mRNA稳定性和翻译调控等过程来影响葡萄糖、脂质和氨基酸的代谢。包括HuR、PTB和YTHDF1在内的RBPs失调与肥胖、糖尿病和非酒精性脂肪性肝病等代谢性疾病有关。TREX技术和转录组分析等技术的进步加深了我们对RBP功能的理解。此外，RBPs有望成为潜在的生物标志物和新疗法的靶点。RBPs未来的研究方向可能集中在组织特异性调节和营养物质与RBP的相互作用上。这可能为更个性化的治疗和改善代谢健康铺平道路。
