Wang Ran, Yu Yifei F, Yu Weiru R, Sun Siyuan Y, Lei Yumei M, Li Yixuan X, Lu Chenxu X, Zhai Jianan N, Bai Feirong R, Ren Fazheng, Huang Jiaqiang Q, Chen Juan
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
J Nutr. 2025 Jan;155(1):37-51. doi: 10.1016/j.tjnut.2024.11.011. Epub 2024 Nov 17.
Probiotics, prebiotics, and postbiotics can significantly influence B-cell-related diseases through their immunomodulatory effects. They enhance the immune system's function, particularly affecting B cells, which originate in the bone marrow and are crucial for antibody production and immune memory. These substances have therapeutic potential in managing allergies, autoimmune diseases, and inflammatory conditions by regulating the gut microbiota, strengthening epithelial barriers, and directly interacting with various components of the innate and adaptive immune systems. The review highlights the critical need for further research into the precise mechanisms through which probiotics, prebiotics, and postbiotics modulate B cells. Gaining this understanding could facilitate the development of more effective treatments for B-cell-related diseases by harnessing the immunomodulatory properties of these dietary components.
益生菌、益生元及后生元可通过其免疫调节作用显著影响与B细胞相关的疾病。它们可增强免疫系统的功能，尤其对起源于骨髓且在抗体产生和免疫记忆方面至关重要的B细胞产生影响。这些物质通过调节肠道微生物群、强化上皮屏障以及直接与先天性和适应性免疫系统的各种成分相互作用，在治疗过敏、自身免疫性疾病和炎症性疾病方面具有治疗潜力。该综述强调了迫切需要进一步研究益生菌、益生元及后生元调节B细胞的精确机制。了解这些机制有助于通过利用这些膳食成分的免疫调节特性，开发出针对与B细胞相关疾病的更有效治疗方法。
