Lima Lorena Almeida, Moura Euler Eduardo Lisboa de, Fraga Schauana Freitas, Contri Renata Vidor, Külkamp-Guerreiro Irene Clemes
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
Graduação em Química Bacharelado, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
Pharmaceutics. 2025 Jun 25;17(7):828. doi: 10.3390/pharmaceutics17070828.
This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery. It assessed the physicochemical properties and in vitro administration performance in pediatric nasogastric tubes and preliminarily evaluated toxicity in a brine shrimp lethality model. The nanocarrier formulation was characterized in terms of the particle size and drug release properties and was compared with extemporaneous formulations prepared using nifedipine tablets in flow rate tests through pediatric feeding tubes. The recovery efficiency was evaluated across different tube sizes and rinsing volumes. A preliminary toxicity study was conducted using a brine shrimp lethality model. Compared with nifedipine tablets, the nanocarrier formulation demonstrated favorable physicochemical properties, including controlled release and superior flow rates, in the pediatric tubes. Full recovery of the nifedipine content was achieved with the nanocarrier formulation, whereas extemporaneous formulation of the nifedipine recovery depended on the tube dimensions and rinsing protocols. Compared with the traditional formulations, the nanocarrier formulation represents a promising alternative for administering nifedipine via pediatric feeding tubes, offering an enhanced administration recovery.
本研究聚焦于开发一种用于硝苯地平递送的基于植烷三醇的无有机溶剂立方液晶纳米粒制剂。评估了其理化性质以及在小儿鼻胃管中的体外给药性能，并在卤虫致死模型中初步评估了毒性。对纳米载体制剂的粒径和药物释放特性进行了表征，并在通过小儿喂食管的流速测试中与使用硝苯地平片制备的临时制剂进行了比较。在不同管径和冲洗体积下评估了回收效率。使用卤虫致死模型进行了初步毒性研究。与硝苯地平片相比，纳米载体制剂在小儿喂食管中表现出良好的理化性质，包括控释和优异的流速。纳米载体制剂可实现硝苯地平含量的完全回收，而硝苯地平临时制剂的回收则取决于管径和冲洗方案。与传统制剂相比，纳米载体制剂是通过小儿喂食管给药硝苯地平的一种有前景的替代方案，可提高给药回收率。
