Algül Derya, Kılıç Ertuğrul, Özkan Ferda, Yağan Uzuner Yasemin
Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, 34755 Kayışdağı, Istanbul, Turkey.
Department of Physiology, School of Medicine, Medeniyet University, 34700 Uskudar, Istanbul, Turkey.
Pharmaceutics. 2025 Jul 21;17(7):941. doi: 10.3390/pharmaceutics17070941.
: To prepare two different kinds of wound care creams containing plant extracts and examine their effectiveness in comparison with a placebo cream and a commercial wound care cream, Madecassol. : The two cream formulations were developed using the same placebo cream (PC) as base cream. One formulation contained balsam of oriental sweet gum, or Levant storax, named as Levant Storax Cream (LSC); the other contained oil of Calendula, extract of St. John's Wort, aescin (an extract of horse chestnut), and freeze-dried powder from Aloe vera (L.) Burm. f. leaf juice, designated as Complex Cream (CC). In the characterization of the creams, organoleptic properties, pH, viscosity, size distribution, and zeta potential of oil globules were measured. Furthermore, the stability of the creams was assessed under different environmental conditions. In vitro studies were performed by using an excisional wound model in rats to assess the potential of the creams for stimulating wound healing. The efficacy of LSC and CC was compared with a commercial reference cream, Madecassol (M), and the placebo control. The study was also designed with a negative control group of rats that were not treated but handled the same way as the other treatment groups. The wound contraction rate, total skin thickness recovery, and results of histopathological parameter examinations were used to compare the effectiveness of the treatments. The stability of formulated creams confirmed that they were stable for the duration of the study. In vivo studies showed that rats treated with LSC achieved the highest wound healing rates when compared with the other groups. A better response was recorded for the CC-treated population when compared to both control and placebo groups, but there was no significant difference seen in healing score between CC and M groups.
制备两种含植物提取物的不同伤口护理乳膏，并与安慰剂乳膏和市售伤口护理乳膏马德卡索（Madecassol）比较其有效性。两种乳膏配方均以相同的安慰剂乳膏（PC）作为基础乳膏开发。一种配方含有苏合香，即黎凡特安息香，命名为黎凡特安息香乳膏（LSC）；另一种含有金盏花油、圣约翰草提取物、七叶皂苷（七叶树提取物）和库拉索芦荟（Aloe vera (L.) Burm. f.）叶汁冻干粉，命名为复方乳膏（CC）。在乳膏特性研究中，测量了感官特性、pH值、粘度、油滴大小分布和zeta电位。此外，还评估了乳膏在不同环境条件下的稳定性。通过大鼠切除伤口模型进行体外研究，以评估乳膏促进伤口愈合的潜力。将LSC和CC的疗效与市售对照乳膏马德卡索（M）和安慰剂对照进行比较。该研究还设计了一个未接受治疗但处理方式与其他治疗组相同的大鼠阴性对照组。使用伤口收缩率、皮肤总厚度恢复情况和组织病理学参数检查结果来比较治疗效果。配方乳膏的稳定性证实其在研究期间是稳定的。体内研究表明，与其他组相比，用LSC治疗的大鼠伤口愈合率最高。与对照组和安慰剂组相比，CC治疗组的反应更好，但CC组和M组在愈合评分上没有显著差异。
