Soler Wenglein Janina, Scarsella Luca, Kotlewski Christine, Heim Albert, Aydin Malik
Department of Pediatrics, Protestant Hospital of the Bethel Foundation, Medical School and University Medical Center East Westphalia-Lippe, Bielefeld University, 33617 Bielefeld, Germany.
Laboratory of Experimental Pediatric Pneumology and Allergology, Department of Human Medicine, Faculty of Health, Witten/Herdecke University, 58453 Witten, Germany.
Viruses. 2025 Jun 27;17(7):914. doi: 10.3390/v17070914.
Human adenoviruses (HAdVs) are pathogens causing different illnesses, particularly in pediatric and immunocompromised patients in developed countries. The clinical spectrum of HAdV-infections ranges from mild to severe, and the clinical presentation varies widely. Certain HAdVs types, including types B3, E4, B7, B14, B21, G55, and B66, may be associated with lower respiratory tract infections and thus lead to higher hospitalization, increased morbidity, as well as lethality rates. The aim of this article is to synthesize and analyze the prevalence of specific HAdV types in pediatric patients worldwide. A systematic literature search was performed using MEDLINE, Scopus, and Web of Science. In total, = 1167 titles and abstracts were screened, and 105 full-text articles were assessed for eligibility. Screening, data extraction, and appraisal were analyzed by reviewers, in accordance with PRISMA guidelines and JBI recommendations. We included studies reporting on currently circulating HAdV types ( = 16). Based on a systematic and narrative approach, relevant types of HAdV biology and infections in children are presented. In detail, HAdV-B3 and HAdV-B7 were commonly associated with severe respiratory tract infections, while HAdV-F40 and HAdV-F41 caused acute gastroenteritis. Moreover, detailed research revealed the critical role of HAdV-C2 and the necessity for particular attention to HAdVs in acute neurological infections. This comprehensive analysis highlights the significant global distribution and diverse clinical implications of different HAdV types in children, pointing out the need for continued surveillance to better understand HAdVs epidemiology and its implications for public health, and future preventive measures, in particular among vulnerable patients.
人腺病毒（HAdVs）是引发不同疾病的病原体，在发达国家，尤其在儿科患者和免疫功能低下的患者中更为常见。HAdV感染的临床谱从轻度到重度不等，临床表现差异很大。某些HAdV类型，包括B3型、E4型、B7型、B14型、B21型、G55型和B66型，可能与下呼吸道感染有关，从而导致更高的住院率、发病率以及死亡率。本文的目的是综合分析全球儿科患者中特定HAdV类型的流行情况。我们使用MEDLINE、Scopus和科学网进行了系统的文献检索。总共筛选了1167篇标题和摘要，评估了105篇全文文章是否符合要求。评审人员根据PRISMA指南和JBI建议对筛选、数据提取和评估进行了分析。我们纳入了报告当前流行的HAdV类型（共16种）的研究。基于系统的叙述方法，介绍了儿童中HAdV生物学和感染的相关类型。详细来说，HAdV-B3和HAdV-B7通常与严重呼吸道感染有关，而HAdV-F40和HAdV-F41会引发急性肠胃炎。此外，详细研究揭示了HAdV-C2的关键作用以及在急性神经感染中对HAdVs特别关注的必要性。这一全面分析凸显了不同HAdV类型在儿童中的显著全球分布和多样的临床意义，指出需要持续监测，以更好地了解HAdVs的流行病学及其对公共卫生的影响，以及未来的预防措施，尤其是在易感患者中。
