Wargotz E S
Am J Surg Pathol. 1985 Nov;9(11):835-41. doi: 10.1097/00000478-198511000-00007.
A patient underwent cerebral angiography with thorium dioxide (Thorotrast). Six years later, an acne-like eruption of the face and scalp occurred which persisted despite aggressive treatment. Twenty-six years after the angiography he developed chronic lymphocytic leukemia with massive lymphadenopathy. Review of three facial biopsies revealed collections of Thorotrast-laden histiocytes and free thorium dioxide within a background of chronic inflammation and dermal fibrosis. These changes are of the same type described in Thorotrast granulomas of the subcutaneous tissues. There is an increased incidence of myelogenous leukemia in Thorotrast-treated patients; lymphoproliferative disorders, however, are only rarely observed.
一名患者接受了二氧化钍（钍造影剂）脑血管造影。六年后，面部和头皮出现痤疮样皮疹，尽管积极治疗仍持续存在。血管造影26年后，他患上了慢性淋巴细胞白血病并伴有大量淋巴结病。对三次面部活检的复查显示，在慢性炎症和皮肤纤维化的背景下，有载有二氧化钍的组织细胞聚集和游离二氧化钍。这些变化与皮下组织钍造影剂肉芽肿中描述的类型相同。接受钍造影剂治疗的患者中骨髓性白血病的发病率增加；然而，淋巴增殖性疾病仅很少见。
