Wang Longfei, Hu Jingyi, Zhou Meng, Yuan Huaen, Lu Huan, Chen Jingyi, Zhao Mengyu, Xiao Menglan, Zhao Mingqin, Lai Miao
Flavors and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China.
Flavors and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China.
Carbohydr Polym. 2025 Oct 15;366:123931. doi: 10.1016/j.carbpol.2025.123931. Epub 2025 Jun 20.
Heterocyclic fragrance compounds possess unique aromas that can enhance flavor of products, but their applications are limited due to high volatility, short storage durations, and thermal instability. This paper used porphyrin grafted carboxymethyl chitosan (CMCS) as wall material and selected four heterocyclic fragrance compounds as core materials to develop an effective controlled release system of photothermal-responsive microcapsules. The optimal preparation process for microcapsules was determined through response surface methodology (RSM). The Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and Flourier transform Infrared Spectroscopy (FTIR) results confirmed the successful preparation of microcapsules. Photo-release performance and thermo-gravimetry (TG) demonstrated excellent photothermal-responsive behavior. The results of MD indicated that the system of microcapsule exhibited enhanced stability and superior convergence, with van der Waals forces being the primary interaction between hosts and guests. Notably, the 3-acetylpyridine/5-(p-aminophenyl)-10,15,20-triphenylporphyrin-carboxymethyl chitosan (ATPD/AC) displayed strongest intermolecular force among the other microcapsules, which performed the highest complexation strength with guest and the highest stability. This study provided a theoretical foundation for constructing stable controlled release systems for heterocyclic fragrance microcapsules.
杂环香料化合物具有独特的香气，能够提升产品风味，但由于其挥发性高、储存期短和热不稳定性，其应用受到限制。本文以卟啉接枝羧甲基壳聚糖（CMCS）为壁材，选择四种杂环香料化合物为芯材，研制出一种有效的光热响应型微胶囊控释体系。通过响应面法（RSM）确定了微胶囊的最佳制备工艺。扫描电子显微镜（SEM）、透射电子显微镜（TEM）和傅里叶变换红外光谱（FTIR）结果证实微胶囊制备成功。光释放性能和热重分析（TG）表明其具有优异的光热响应行为。分子动力学（MD）结果表明，微胶囊体系表现出更高的稳定性和更好的收敛性，范德华力是主体与客体之间的主要相互作用。值得注意的是，3-乙酰基吡啶/5-（对氨基苯基）-10,15,20-三苯基卟啉-羧甲基壳聚糖（ATPD/AC）在其他微胶囊中表现出最强的分子间作用力，与客体的络合强度最高，稳定性也最高。本研究为构建稳定的杂环香料微胶囊控释体系提供了理论依据。
