Schröder H J, Ottermann U
Anasth Intensivther Notfallmed. 1985 Aug;20(4):206-9.
In a primigravida of 25 years of age who had an attack of eclampsia seven hours after Caesarean section we found an abnormally low oncotic pressure (i.e. colloid osmotic pressure, COP) in the plasma, namely, 14.5 mm Hg instead of the normal value which is greater than 20mm Hg. In EPH-gestosis there is a pathogenetic dependence of the oedemas, hypovolaemia, haemoconcentration and insufficient perfusion of parenchymatous organs, on the transcapillary colloid osmotic pressure gradient. As a result of colloid substitution with human albumin (20-40 g per day) effected with oncometric control, the COP increased stepwise to 18.3 mm Hg within one week and the distribution of fluid between the intravascular and extravascular space normalised. Repeated direct measurement of the colloid osmotic pressure (in our case by Onkometer BMT 921, Thomae) proved extremely helpful especially as a means of therapy control.
在一名25岁的初产妇中，她在剖宫产术后7小时发生子痫，我们发现其血浆中胶体渗透压（即COP）异常低，仅为14.5毫米汞柱，而正常值应大于20毫米汞柱。在妊娠高血压综合征中，水肿、血容量减少、血液浓缩以及实质器官灌注不足在发病机制上依赖于跨毛细血管胶体渗透压梯度。通过用人白蛋白进行胶体替代（每天20 - 40克）并进行渗透压监测，胶体渗透压在一周内逐步升至18.3毫米汞柱，血管内和血管外空间的液体分布恢复正常。重复直接测量胶体渗透压（在我们的案例中使用托马公司的Onkometer BMT 921）被证明非常有用，特别是作为一种治疗监测手段。
