Abel M
Klin Padiatr. 1985 Sep-Oct;197(5):392-7. doi: 10.1055/s-2008-1034010.
The clinical significance of colloid osmotic pressure (COP) in transcapillary fluid exchange and water homeostasis in health and disease is described. Under pathophysiological circumstances measurement of COP should be preferred to COP value calculation. After extensive COP experiences in critically ill adults and numerous refinements in COP monitoring technology, COP studies in neonates and paediatric intensive care patients have been published recently. In these patients hypovolaemia and need of volume replacement therapy are often associated with an increase in capillary permeability. Therefore prevention of general and interstitial colloid and fluid overload is a permanent challenge in the care of the young critically ill patient; e.g. in a case report. Consequently regular COP measurements should be considered in paediatric intensive care, especially in case of oncotic volume replacement therapy.
本文描述了胶体渗透压（COP）在健康和疾病状态下跨毛细血管液体交换及水平衡中的临床意义。在病理生理情况下，应优先进行COP测量而非计算COP值。在危重症成人中积累了丰富的COP测量经验且COP监测技术有了诸多改进之后，近期已发表了关于新生儿和儿科重症监护患者的COP研究。在这些患者中，低血容量和需要进行容量替代治疗常常与毛细血管通透性增加相关。因此，在照顾年幼的危重症患者时，预防全身性和间质胶体及液体过载始终是一项挑战；例如在一份病例报告中。因此，在儿科重症监护中应考虑定期测量COP，尤其是在进行胶体渗透压性容量替代治疗的情况下。
