Oosterwijk Valerie A, Gao Caroline X, Menssink Jana, Nguyen Josh, Filia Kate, Watson Amity E, Herrman Helen, Hetrick Sarah E, Parker Alex G, Hickie Ian B, Rickwood Debra, McGorry Patrick D, Cotton Susan M, Schmaal Lianne, Tagliaferri Scott D
Faculty of Medicine, https://ror.org/008xxew50Vrije Universiteit, Amsterdam, The Netherlands.
Orygen, Parkville, VIC, Australia.
Psychol Med. 2025 Jul 30;55:e207. doi: 10.1017/S0033291725101104.
Mental ill-health has a major impact on young people, with pain often co-occurring. We estimated the prevalence and impact of pain in young people with mental ill-health.
Longitudinal data (baseline and three-month follow-up) of 1,107 Australian young people (aged 12-25 years) attending one of five youth mental health services. Multi-level linear mixed models estimated associations between pain characteristics (frequency, intensity, and limitations) and outcomes with false discovery rate (FDR) adjustment. Pain characteristics were baseline-centered to estimate if the baseline score () and/or change from baseline ( was associated with outcomes.
At baseline, 16% reported serious pain more than 3 days, 51% reported at least moderate pain, and 25% reported pain-related activity limitations in the last week. Between participants, higher serious pain frequency was associated with greater anxiety symptoms ([95%CI]: 0.90 [0.45, 1.35], FDR-p=0.001), higher pain intensity was associated with greater symptoms of depression (1.50 [0.71, 2.28], FDR-p=0.001), anxiety (1.22 [0.56, 1.89], FDR-p=0.002), and suicidal ideation (3.47 [0.98, 5.96], FDR-p=0.020), and higher pain limitations were associated with greater depressive symptoms (1.13 [0.63, 1.63], FDR-p<0.001). Within participants, increases in pain intensity were associated with increases in tobacco use risk (1.09 [0.48, 1.70], FDR-p=0.002), and increases in pain limitations were associated with increases in depressive symptoms (0.99 [0.54, 1.43], FDR-p<0.001) and decreases in social and occupational functioning (-1.08 [-1.78, -0.38], FDR-p=0.009).
One-in-two young people seeking support for mental ill-health report pain. Youth mental health services should consider integrating pain management.
心理健康问题对年轻人有重大影响，疼痛常常与之并存。我们估计了有心理健康问题的年轻人中疼痛的患病率及影响。
对1107名澳大利亚年轻人（年龄在12至25岁之间）进行纵向数据收集（基线和三个月随访），这些年轻人均接受了五个青少年心理健康服务机构之一的服务。采用多层次线性混合模型估计疼痛特征（频率、强度和限制）与结果之间的关联，并进行错误发现率（FDR）调整。疼痛特征以基线为中心，以估计基线分数（）和/或相对于基线的变化（是否与结果相关。
在基线时，16%的人报告严重疼痛超过3天，51%的人报告至少中度疼痛，25%的人报告上周有与疼痛相关的活动受限。在参与者之间，较高的严重疼痛频率与更严重的焦虑症状相关（[95%置信区间]：0.90[0.45，1.35]，FDR-p = 0.001），较高的疼痛强度与更严重的抑郁症状（1.50[0.71，2.28]，FDR-p = 0.001）、焦虑（1.22[0.56，1.89]，FDR-p = 0.002）和自杀意念（3.47[0.98，5.96]，FDR-p = 0.020）相关，较高的疼痛限制与更严重的抑郁症状相关（1.13[0.63，1.63]，FDR-p<0.001）。在参与者内部，疼痛强度的增加与吸烟风险增加相关（1.09[0.48,1.70]，FDR-p = 0.002），疼痛限制的增加与抑郁症状增加相关（0.99[0.54,1.43]，FDR-p<0.001）以及社会和职业功能下降相关（-1.08[-1.78，-0.38]，FDR-p = 0.009）。
每两个寻求心理健康问题支持的年轻人中就有一个报告有疼痛。青少年心理健康服务机构应考虑纳入疼痛管理。
