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本文引用的文献

1
Psychopharmacological strategies in the management of posttraumatic stress disorder (PTSD): what have we learned?创伤后应激障碍（PTSD）的精神药理学治疗策略：我们学到了什么？
Curr Psychiatry Rep. 2015 Apr;17(4):564. doi: 10.1007/s11920-015-0564-2.
2
Changes in comorbid conditions after prolonged exposure for PTSD: a literature review.创伤后应激障碍长期暴露后共病状况的变化：一项文献综述。
Curr Psychiatry Rep. 2015 Mar;17(3):549. doi: 10.1007/s11920-015-0549-1.
3
Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis.创伤后应激障碍的药物治疗：系统评价和荟萃分析。
Br J Psychiatry. 2015 Feb;206(2):93-100. doi: 10.1192/bjp.bp.114.148551.
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FKBP5 allele-specific epigenetic modification in gene by environment interaction.基因中FKBP5等位基因特异性表观遗传修饰的基因与环境相互作用
Neuropsychopharmacology. 2015 Jan;40(1):244-6. doi: 10.1038/npp.2014.208.
5
Comorbidity of 9/11-related PTSD and depression in the World Trade Center Health Registry 10-11 years postdisaster.世贸中心健康登记处灾后10 - 11年与9·11相关的创伤后应激障碍和抑郁症的共病情况。
J Trauma Stress. 2014 Dec;27(6):680-8. doi: 10.1002/jts.21972. Epub 2014 Dec 2.
6
Epigenetic signaling in psychiatric disorders: stress and depression.精神疾病中的表观遗传信号传导：压力与抑郁
Dialogues Clin Neurosci. 2014 Sep;16(3):281-95. doi: 10.31887/DCNS.2014.16.3/rbagot.
7
Altered functional connectivity in posttraumatic stress disorder with versus without comorbid major depressive disorder: a resting state fMRI study.创伤后应激障碍伴与不伴共病重度抑郁症时的功能连接改变：一项静息态功能磁共振成像研究
F1000Res. 2013 Dec 30;2:289. doi: 10.12688/f1000research.2-289.v2. eCollection 2013.
8
Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and outcome.皮质醇增强心理治疗对患有创伤后应激障碍的战士的疗效：随机试验表明治疗依从性和治疗效果得到改善。
Psychoneuroendocrinology. 2015 Jan;51:589-97. doi: 10.1016/j.psyneuen.2014.08.004. Epub 2014 Aug 13.
9
DSM-5 and ICD-11 definitions of posttraumatic stress disorder: investigating "narrow" and "broad" approaches.DSM-5 和 ICD-11 创伤后应激障碍定义：探讨“狭义”和“广义”方法。
Depress Anxiety. 2014 Jun;31(6):494-505. doi: 10.1002/da.22279.
10
Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the U.S. Army.美国陆军中与创伤后应激障碍（PTSD）、抑郁症及其共病相关的自杀行为风险。
J Affect Disord. 2014 Jun;161:116-22. doi: 10.1016/j.jad.2014.03.016. Epub 2014 Mar 25.

创伤后应激障碍与重度抑郁症之间的共病：其他解释及治疗考量

Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations.

作者信息

Flory Janine D, Yehuda Rachel

机构信息

James J. Peters Veterans Affairs Medical Center, Bronx, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.

James J. Peters Veterans Affairs Medical Center, Bronx, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA.

出版信息

Dialogues Clin Neurosci. 2015 Jun;17(2):141-50. doi: 10.31887/DCNS.2015.17.2/jflory.

DOI:10.31887/DCNS.2015.17.2/jflory
PMID:26246789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4518698/
Abstract

Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from Major Depressive Disorder (MDD). The current paper examines evidence for two explanations of this comorbidity. First, that the comorbidity reflects overlapping symptoms in the two disorders. Second, that the co-occurrence of PTSD and MDD is not an artifact, but represents a trauma-related phenotype, possibly a subtype of PTSD. Support for the latter explanation is inferred from literature that examines risk and biological correlates of PTSD and MDD, including molecular processes. Treatment implications of the comorbidity are considered.

摘要

约半数创伤后应激障碍（PTSD）患者同时患有重度抑郁症（MDD）。本文考察了对这种共病现象的两种解释的证据。第一种解释是，共病反映了这两种障碍中重叠的症状。第二种解释是，PTSD和MDD的同时出现并非人为现象，而是代表了一种与创伤相关的表型，可能是PTSD的一个亚型。对后一种解释的支持来自于考察PTSD和MDD的风险及生物学关联（包括分子过程）的文献。文中还考虑了这种共病现象对治疗的影响。