创伤后应激障碍与重度抑郁症之间的共病：其他解释及治疗考量
Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations.
作者信息
Flory Janine D, Yehuda Rachel
机构信息
James J. Peters Veterans Affairs Medical Center, Bronx, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
James J. Peters Veterans Affairs Medical Center, Bronx, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA.
出版信息
Dialogues Clin Neurosci. 2015 Jun;17(2):141-50. doi: 10.31887/DCNS.2015.17.2/jflory.
Abstract
Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from Major Depressive Disorder (MDD). The current paper examines evidence for two explanations of this comorbidity. First, that the comorbidity reflects overlapping symptoms in the two disorders. Second, that the co-occurrence of PTSD and MDD is not an artifact, but represents a trauma-related phenotype, possibly a subtype of PTSD. Support for the latter explanation is inferred from literature that examines risk and biological correlates of PTSD and MDD, including molecular processes. Treatment implications of the comorbidity are considered.
摘要
约半数创伤后应激障碍（PTSD）患者同时患有重度抑郁症（MDD）。本文考察了对这种共病现象的两种解释的证据。第一种解释是，共病反映了这两种障碍中重叠的症状。第二种解释是，PTSD和MDD的同时出现并非人为现象，而是代表了一种与创伤相关的表型，可能是PTSD的一个亚型。对后一种解释的支持来自于考察PTSD和MDD的风险及生物学关联（包括分子过程）的文献。文中还考虑了这种共病现象对治疗的影响。
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