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尼日利亚乌穆阿希亚阿比亚州专科医院及诊断中心2型糖尿病患者临床肾病的患病率及其相关因素:一项横断面研究

Prevalence and Correlates of Clinical Nephropathy in Patients With Type 2 Diabetes at Abia State Specialist Hospital and Diagnostic Center, Umuahia, Nigeria: A Cross-Sectional Study.

作者信息

Okeji Izuchukwu E, Uzor Onyedikachi F, Okafor Christopher C, Okafor Silas U, Airaodion Augustine I, Orji Obinna J, Abali Isaiah O, Esangbedo Ikpembhosa J, Jolaoye Oladoyin Ogunbayo, Olaotan Temitayo O, Zacs Innocent Chima, Umeh Akudo B, Ojumonu Ugonna Emmanuella, Ekwere Abasiekeme Monday, Madueke Cynthia Kenechukwu, Austin-Jemifor Ochuko, Victor-Anozie Excel Nwasinachi, Amuta Augustine C, Umeh Chibuike

机构信息

General Medicine, North Cumbria Integrated Care, NHS Foundation Trust, North Cumbria, GBR.

General Practice, General Practice/Forge Health Sheffield Teaching Hospital, Sheffield, GBR.

出版信息

Cureus. 2025 Jun 29;17(6):e86962. doi: 10.7759/cureus.86962. eCollection 2025 Jun.

Abstract

Background Clinical nephropathy is a prevalent and serious microvascular complication of type 2 diabetes mellitus (T2DM), contributing substantially to increased morbidity and mortality among affected individuals. It often progresses insidiously, leading to end-stage renal disease if not promptly detected and managed. Despite its growing public health importance, there is a paucity of region-specific data on the prevalence and correlates of clinical nephropathy in patients with T2DM, particularly in resource-limited settings. In regions such as Abia State, Nigeria, limited research has been conducted to determine the burden of diabetic nephropathy and its clinical correlates. Understanding the local epidemiology of this complication is essential for guiding early detection strategies, optimizing management, and improving patient outcomes. Objective This study investigates the prevalence and correlates of clinical nephropathy among patients with type 2 diabetes at Abia State Specialist Hospital and Diagnostic Center, Nigeria, to inform strategies for improving early detection and management of diabetic nephropathy complications. Methodology A cross-sectional study design was employed at the Abia State Specialist Hospital and Diagnostic Center outpatient clinic. The sample size ( = 255) was calculated using the Cochran formula, considering a known prevalence of nephropathy in patients with T2DM in Nigeria. Data were collected through structured interviews, clinical examinations, and laboratory procedures, and analyzed using IBM SPSS Statistics for Windows, Version 20 (IBM Corp., Armonk, NY). Results Clinical information indicated a high prevalence of clinical nephropathy (77, 30.20%). Lifestyle factors reflected low tobacco use (25, 9.80%) and alcohol consumption (32, 12.55%), with frequent engagement in physical activity (87, 34.12%). Access to healthcare revealed barriers (174, 68.24%) and limited knowledge of diabetic kidney disease (77, 30.20%). Anthropometric indices and blood pressure showed significant differences between groups ( < 0.05), with diabetic patients with nephropathy exhibiting higher values. Renal indices also displayed significant differences ( < 0.05), indicating renal dysfunction among diabetic patients with nephropathy. The prevalence of albuminuria was notable (microalbuminuria: 156, 61.18%). The staging of clinical nephropathy revealed varying severity levels. Conclusions The clinical nephropathy prevalence among patients with T2DM at Abia State Specialist Hospital and Diagnostic Center, Umuahia, Nigeria, is substantial. Factors such as anthropometric indices, blood pressure, renal parameters, glycemic control, and lipid profiles significantly correlate with the presence of nephropathy. These findings underscore the importance of early detection and management strategies to mitigate diabetic nephropathy complications.

摘要

背景

临床肾病是2型糖尿病(T2DM)常见且严重的微血管并发症,极大地增加了患者的发病率和死亡率。它通常隐匿进展,若不及时发现和处理,会导致终末期肾病。尽管其对公众健康的重要性日益增加,但关于T2DM患者临床肾病的患病率及相关因素,尤其是在资源有限地区的区域特异性数据却很匮乏。在尼日利亚阿比亚州等地区,针对糖尿病肾病负担及其临床相关因素的研究有限。了解这种并发症的当地流行病学情况对于指导早期检测策略、优化管理以及改善患者预后至关重要。

目的

本研究调查尼日利亚阿比亚州专科医院及诊断中心2型糖尿病患者临床肾病的患病率及相关因素,为改善糖尿病肾病并发症的早期检测和管理策略提供依据。

方法

在阿比亚州专科医院及诊断中心门诊采用横断面研究设计。使用 Cochr an公式计算样本量(n = 255),同时考虑到尼日利亚T2DM患者中已知的肾病患病率。通过结构化访谈、临床检查和实验室检测收集数据,并使用IBM SPSS Statistics for Windows 20版(IBM公司,纽约州阿蒙克)进行分析。

结果

临床信息显示临床肾病患病率较高(77例,30.20%)。生活方式因素表明吸烟率较低(25例,9.80%),饮酒率较低(32例,12.55%),经常进行体育锻炼的比例较高(87例,34.12%)。获得医疗服务存在障碍(174例,68.24%),对糖尿病肾病的了解有限(77例,30.20%)。人体测量指标和血压在各组间存在显著差异(P < 0.05),患有肾病的糖尿病患者数值更高。肾脏指标也存在显著差异(P < 0.05),表明患有肾病的糖尿病患者存在肾功能障碍。蛋白尿患病率值得关注(微量白蛋白尿:156例,61.18%)。临床肾病分期显示出不同的严重程度。

结论

在尼日利亚乌穆阿希亚的阿比亚州专科医院及诊断中心,T2DM患者的临床肾病患病率较高。人体测量指标、血压、肾脏参数、血糖控制和血脂谱等因素与肾病的存在显著相关。这些发现强调了早期检测和管理策略对于减轻糖尿病肾病并发症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/12306514/9ccaa458f962/cureus-0017-00000086962-i01.jpg

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