Suppr超能文献

揭示精准医学领域的差异:一种观点。

Unveiling the Disparities in the Field of Precision Medicine: A Perspective.

作者信息

Morsi Maha Hosni, Elawfi Bashaer, ALsaad Saad Ashraf, Nazar Ahmed, Mostafa Hamed Abdelma'aboud, Awwad Sara Adel, Abdelwahab Maya Magdy, Tarakhan Husam, Baghagho Ehssan

机构信息

Clinical and Chemical Pathology Department, Faculty of Applied Health Sciences Technology Misr University for Sciences and Technology Giza City Egypt.

Medical Research Group of Egypt Negida Academy LLC Arlington Massachusetts USA.

出版信息

Health Sci Rep. 2025 Jul 27;8(8):e71102. doi: 10.1002/hsr2.71102. eCollection 2025 Aug.

Abstract

BACKGROUND AND AIM

Precision medicine prescribes medication based on genetic data, social history, and environment, offering more effective care. This article presumes that many disparities shatter this promise for numerous groups. The article discusses the challenges of personalized medicine in relation to disparities, proposes solutions, and introduces strategies to address these issues.

METHODS

A comprehensive literature review was done to understand precision medicine, its implementation challenges, and possible answers. Academic databases, including Google Scholar, PubMed, and Scopus, were searched for relevant studies and peer-reviewed articles. Peer-reviewed precision medicine articles in oncology, internal medicine, public health, and obstetrics and gynecology were included to provide a broad and interdisciplinary perspective.

RESULTS

The concept of precision medicine needs to be implemented throughout many levels of society and healthcare systems around the world. Access to genomic data is limited in high-income countries, and socioeconomic disparities hinder healthcare equality, particularly for low-income individuals or those without insurance. The digital divide, lack of education, ethical concerns, and regulatory frameworks contribute to disparities in personalized medicine. We believe that health equity will be achieved by addressing these discrepancies and suggesting some strategies to overcome them.

CONCLUSION

Precision medicine has successfully treated and helped in the early detection of many diseases, like severe asthma, cancer, and type 1 diabetes. Socioeconomic position, education, data, access, and regulatory frameworks prevent minorities and low-income populations from using it. For instance, lack of awareness and other inequalities in access to precision medicine limit T1DM HLA typing and autoantibody surveillance. These discrepancies must be addressed to improve minority and low-income T1DM patients' outcomes. The patient-oriented strategy is cost-effective and includes benefits through education, genetic data diversity promotion, and increased access, but regulatory frameworks are essential.

摘要

背景与目的

精准医学根据基因数据、社会病史和环境来开处方用药,提供更有效的治疗。本文假定许多差异使这一承诺对众多群体无法实现。本文讨论了个性化医疗在差异方面面临的挑战,提出了解决方案,并介绍了应对这些问题的策略。

方法

进行了全面的文献综述,以了解精准医学、其实施挑战及可能的应对方法。在包括谷歌学术、PubMed和Scopus在内的学术数据库中搜索相关研究和同行评审文章。纳入肿瘤学、内科、公共卫生以及妇产科领域经同行评审的精准医学文章,以提供广泛的跨学科视角。

结果

精准医学的概念需要在全球社会和医疗系统的多个层面得到实施。在高收入国家,获取基因组数据的机会有限,社会经济差异阻碍了医疗平等,尤其是对低收入个人或无保险者而言。数字鸿沟、缺乏教育、伦理问题和监管框架导致了个性化医疗中的差异。我们认为,通过解决这些差异并提出一些克服它们的策略,将实现健康公平。

结论

精准医学已成功治疗并有助于多种疾病的早期检测,如重度哮喘、癌症和1型糖尿病。社会经济地位、教育、数据、获取途径和监管框架使少数群体和低收入人群无法使用精准医学。例如,对精准医学缺乏认识以及其他获取方面的不平等限制了1型糖尿病的HLA分型和自身抗体监测。必须解决这些差异,以改善少数群体和低收入1型糖尿病患者的治疗效果。以患者为导向的策略具有成本效益,包括通过教育、促进基因数据多样性和增加获取途径带来的益处,但监管框架至关重要。

相似文献

1
Unveiling the Disparities in the Field of Precision Medicine: A Perspective.揭示精准医学领域的差异:一种观点。
Health Sci Rep. 2025 Jul 27;8(8):e71102. doi: 10.1002/hsr2.71102. eCollection 2025 Aug.

本文引用的文献

1
Economic Perspective of the Use of Wearables in Health Care: A Systematic Review.可穿戴设备在医疗保健中应用的经济学视角:一项系统综述。
Mayo Clin Proc Digit Health. 2024 May 14;2(3):299-317. doi: 10.1016/j.mcpdig.2024.05.003. eCollection 2024 Sep.
2
A Review of the Regulatory Challenges of Personalized Medicine.个性化医疗监管挑战综述
Cureus. 2024 Aug 27;16(8):e67891. doi: 10.7759/cureus.67891. eCollection 2024 Aug.
4
Immunopeptidome mining reveals a novel ERS-induced target in T1D.免疫肽组学挖掘揭示了 T1D 中一种新型 ERS 诱导的靶标。
Cell Mol Immunol. 2024 Jun;21(6):604-619. doi: 10.1038/s41423-024-01150-0. Epub 2024 Apr 30.
7
Precision Medicine in Type 1 Diabetes.1型糖尿病的精准医学
J Indian Inst Sci. 2023;103(1):335-351. doi: 10.1007/s41745-023-00356-x. Epub 2023 Mar 7.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验