Takagishi Yuriko, Ito Masaya, Kuga Hironori, Horikoshi Masaru
National Center for Cognitive Behavior Therapy and Research National Center of Neurology and Psychiatry Kodaira Japan.
Institute of Human Sciences University of Tsukuba Tsukuba Japan.
PCN Rep. 2025 Jul 28;4(3):e70163. doi: 10.1002/pcn5.70163. eCollection 2025 Sep.
The association between alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) is well established. However, many studies in Japan have focused on trauma related to natural disasters, which differ from international studies that include several trauma types. We examined whether trauma exposure and PTSD are associated with AUD risk across diverse trauma types. Additionally, because gender differences in drinking patterns and AUD may vary by country, we explored whether findings from international research hold in a Japanese context.
An online survey of 6180 Japanese adults included 25 items from the World Health Organization's traumatic event list, the PTSD Checklist-5, and the CAGE Questionnaire. Of these, 5150 reported exposure to traumatic events, and 1030 reported no exposure.
Participants' mean age was 43.79 years, and 52.8% were women. The AUD group comprised more men (59.1%) than the non-AUD group (44.1%). Logistic regression analyses showed that trauma exposure was associated with higher odds ratios (ORs) of AUD among individuals without PTSD (OR = 1.55, 95% confidence interval [CI]: 1.24-1.94) and among those with PTSD (OR = 2.02, 95% CI: 1.62-2.52) compared to those with no trauma exposure. Among women, several non-natural-disaster events showed a higher risk of AUD than that posed by natural disasters. In men, physical violence by a partner was associated with a higher risk.
These findings highlight the pertinence of assessing trauma characteristics and gender when addressing PTSD and AUD. They may inform gender-sensitive interventions and culturally relevant policies targeting individuals at risk for comorbid PTSD and AUD.
酒精使用障碍（AUD）与创伤后应激障碍（PTSD）之间的关联已得到充分证实。然而，日本的许多研究聚焦于与自然灾害相关的创伤，这与包含多种创伤类型的国际研究不同。我们研究了不同创伤类型下创伤暴露和PTSD是否与AUD风险相关。此外，由于饮酒模式和AUD的性别差异可能因国家而异，我们探讨了国际研究结果在日本背景下是否成立。
对6180名日本成年人进行的在线调查包括世界卫生组织创伤事件清单中的25项、PTSD检查表-5和CAGE问卷。其中，5150人报告有创伤事件暴露，1030人报告无暴露。
参与者的平均年龄为43.79岁，52.8%为女性。AUD组男性（59.1%）多于非AUD组（44.1%）。逻辑回归分析显示，与无创伤暴露者相比，在无PTSD的个体中（比值比[OR]=1.55，95%置信区间[CI]：1.24-1.94）以及有PTSD的个体中（OR=2.02，95%CI：1.62-2.52），创伤暴露与更高的AUD比值比相关。在女性中，一些非自然灾害事件显示出比自然灾害更高的AUD风险。在男性中，伴侣的身体暴力与更高风险相关。
这些发现突出了在处理PTSD和AUD时评估创伤特征和性别的相关性。它们可能为针对共病PTSD和AUD风险个体的性别敏感干预措施和文化相关政策提供参考。
