Swannell Megan, Bradlow Richard C J, Pham Daniel, Gabriel Jessica, Manahan Yasmin, Arunogiri Shalini
Eastern Health Mental Health Service, Victoria, Australia.
Turning Point, Eastern Health, Victoria, Australia.
J Subst Use Addict Treat. 2025 Feb;169:209601. doi: 10.1016/j.josat.2024.209601. Epub 2024 Dec 12.
Post-traumatic stress disorder and substance use disorders commonly co-occur and are associated with worse health outcomes. Currently, only psychosocial therapies are specifically recommended for use in the co-occurring population, but these come with numerous barriers to access and engagement. This study aims to identify potential pharmacological treatments to enhance treatment options and outcomes for this population.
This systematic review identified studies on pharmacological treatment of co-occurring PTSD and SUD in humans, using validated outcome measurements, with study design of RCT, observational study, case control study or cohort study.
29 studies were identified for inclusion, looking at a range of 16 pharmacotherapies. A majority concentrated on alcohol use disorders and males, with many focused on the veteran population.
This is an area for further research, inclusive of more SUDs, genders and civilians. Future studies utilizing consistent dosing, populations and measurement outcomes will allow for future meta-analysis.
创伤后应激障碍和物质使用障碍通常同时出现，且与更差的健康结果相关。目前，仅特别推荐心理社会疗法用于同时患有这两种疾病的人群，但这些疗法存在诸多获取和参与障碍。本研究旨在确定潜在的药物治疗方法，以增加该人群的治疗选择并改善治疗结果。
本系统评价通过使用经过验证的结局测量方法，纳入了关于人类同时患有创伤后应激障碍和物质使用障碍的药物治疗研究，研究设计包括随机对照试验、观察性研究、病例对照研究或队列研究。
共纳入29项研究，涉及16种药物疗法。大多数研究集中在酒精使用障碍和男性，许多研究聚焦于退伍军人。
这是一个需要进一步研究的领域，包括更多类型的物质使用障碍、不同性别以及普通人群。未来采用一致给药剂量、研究人群和测量结局的研究将有助于开展未来的荟萃分析。
