Cao Menghan, Shao Zhiying, Qian Xingyou, Chen Miaolei, Deng Chuyin, Chen Xintian, Tang Tingting, Zhang Kaixu, Chu Sufang, Zheng Junnian, Bai Jin, Li Zhongwei
Nanjing Medical University, Nanjing, Jiangsu, China.
Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Cell Death Dis. 2025 Jan 31;16(1):56. doi: 10.1038/s41419-025-07383-9.
Tripartite motif-containing 21 (TRIM21) plays a crucial role in antiviral responses and autoimmune diseases. While the impact of TRIM21 on cancer has been studied in various tumors, its role in colorectal cancer (CRC) remains unclear. In this study, we found that TRIM21 expression is reduced in primary CRC tissues. Low levels of TRIM21 in CRC are associated with unfavorable clinicopathological characteristics and shorter survival. Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. These findings suggest that TRIM21 holds potential as a valuable predictive biomarker for assessing the prognosis of CRC patients.
含三联基序蛋白21（TRIM21）在抗病毒反应和自身免疫性疾病中起关键作用。虽然已在多种肿瘤中研究了TRIM21对癌症的影响，但其在结直肠癌（CRC）中的作用仍不清楚。在本研究中，我们发现原发性CRC组织中TRIM21表达降低。CRC中低水平的TRIM21与不良的临床病理特征和较短的生存期相关。此外，我们证明TRIM21通过促进PRMT1的泛素化介导降解来抑制CRC细胞的增殖、肿瘤发生、迁移和转移。这些发现表明，TRIM21有望成为评估CRC患者预后的有价值的预测生物标志物。
