Sun Fang, Sun Yuyu, He Hongbo, Zhao Zhigang, Zhang Hexuan, Jiang Nan, Zhu Zhiming
Department of Hypertension and Endocrinology Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension Chongqing China.
Department of Endocrinology Qingdao Huangdao District Second Traditional Chinese Medicine Hospital Qingdao China.
Clin Case Rep. 2025 Jul 27;13(8):e70660. doi: 10.1002/ccr3.70660. eCollection 2025 Aug.
Ectopic ACTH secretion-related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here, we present a case of non-small cell lung cancer with metastasis. Due to significant deconditioning, the patient was unable to undergo bilateral adrenalectomy and instead underwent catheter-based adrenal ablation; subsequently, he achieved clinical remission and completed the first phase of chemotherapy.
异位促肾上腺皮质激素（ACTH）分泌相关的库欣综合征可能表现为皮质醇增多症迅速发作、尿游离皮质醇（UFC）和血ACTH浓度升高以及低钾血症。然而，对于原发性病变难以切除的患者，根据指南，推荐的治疗方法是双侧肾上腺切除术。在此，我们报告一例发生转移的非小细胞肺癌病例。由于身体状况极差，该患者无法接受双侧肾上腺切除术，而是接受了基于导管的肾上腺消融术；随后，他实现了临床缓解并完成了第一阶段化疗。
