Sun Fanghui, Liu Yue, Zhang Tao
R&D Center, Better Way (Shanghai) Cosmetics Co., Ltd, Shanghai, People's Republic of China.
J Cosmet Dermatol. 2025 Aug;24(8):e70310. doi: 10.1111/jocd.70310.
Comprehensive exploration of lip aging remains limited due to anatomical complexity of the structure, with current investigations predominantly focusing on aspects such as dryness management, cheilitis prevention and treatment, and surgical lifts.
This article aims to review multiple aspects of lip aging and to explore anti-aging approaches for the lips, thereby providing actionable insights for the development of cosmetic lip care products.
We conducted a literature search in the PubMed database using keywords related to lip aging, and selected the most relevant articles for in-depth reading, summarization, and integration to form the content of this review.
Due to the significant differences between lip and facial skin in terms of barrier function, melanin content, transepidermal absorption capacity, physiological activity frequency, and fat distribution, the aging characteristics of lips also exhibit uniqueness. At the same time, there are gender differences in lip aging manifestations, with women typically showing more noticeable perioral wrinkles compared to men.
The clinical manifestations and pathogenic mechanisms of lip aging differ significantly from those of facial aging, requiring distinct priorities in anti-aging product development. For the vermilion, the focus should be on barrier restoration, mild anti-aging approaches, and photoaging prevention. In contrast, perioral anti-aging may be addressed by inhibiting ECM degradation and enhancing tissue volume. Addressing gender differences can guide the development of anti-aging lip products tailored to women, while managing associated pigmentary changes offers a unique avenue for this purpose.
由于唇部结构的解剖复杂性，对唇部衰老的全面探索仍然有限，目前的研究主要集中在干燥管理、唇炎防治和手术提拉等方面。
本文旨在综述唇部衰老的多个方面，并探索唇部抗衰方法，从而为唇部美容护理产品的开发提供可行的见解。
我们在PubMed数据库中使用与唇部衰老相关的关键词进行文献检索，选择最相关的文章进行深入阅读、总结和整合，以形成本综述的内容。
由于唇部与面部皮肤在屏障功能、黑色素含量、经皮吸收能力、生理活动频率和脂肪分布方面存在显著差异，唇部的衰老特征也表现出独特性。同时，唇部衰老表现存在性别差异，女性的口周皱纹通常比男性更明显。
唇部衰老的临床表现和发病机制与面部衰老有显著差异，在抗衰产品开发中需要有不同的侧重点。对于唇红部，重点应放在屏障修复、温和抗衰方法和光老化预防上。相比之下，口周抗衰可通过抑制细胞外基质降解和增加组织容量来解决。关注性别差异可以指导针对女性的唇部抗衰产品的开发，而处理相关色素变化为此提供了一条独特途径。
