Zou Faxing, Liu Yibiao, Luo Yong, Xu Tailin
Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong 518060, People's Republic of China.
Longgang Central Hospital of Shenzhen, Shenzhen 518116, People's Republic of China.
Sci Adv. 2025 Aug;11(31):eadw1732. doi: 10.1126/sciadv.adw1732. Epub 2025 Jul 30.
The rising prevalence of Alzheimer's disease (AD) due to an aging population has made the search for effective treatments more urgent than ever. Previous studies have demonstrated that continuous ultrasound can depolymerize amyloid proteins, offering potential relief from AD. In this study, we present a portable, fully integrated wearable ultrasound system designed to promote amyloid protein depolymerization. The system comprises a flexible honeycomb ultrasonic array patch, a flexible printed circuit, and an interactive terminal control system to facilitate the treatment process. Our results demonstrate that the system effectively reduces amyloid proteins in the brain, improves cognitive function in a familial Alzheimer's disease (FAD) mouse model, enhances microglial phagocytosis of amyloid-β plaques, and shifts microglia polarization from M1 to M2. These changes contribute to a mitigated inflammatory environment in the brain. This innovative approach may pave the way for noninvasive, personalized treatments for AD, potentially transforming therapeutic strategies in neurodegenerative disorders.
由于人口老龄化，阿尔茨海默病（AD）的患病率不断上升，这使得寻找有效的治疗方法比以往任何时候都更加紧迫。先前的研究表明，连续超声可以使淀粉样蛋白解聚，为缓解AD提供了可能。在本研究中，我们展示了一种便携式、完全集成的可穿戴超声系统，旨在促进淀粉样蛋白解聚。该系统包括一个柔性蜂窝状超声阵列贴片、一个柔性印刷电路和一个交互式终端控制系统，以方便治疗过程。我们的结果表明，该系统有效地减少了大脑中的淀粉样蛋白，改善了家族性阿尔茨海默病（FAD）小鼠模型的认知功能，增强了小胶质细胞对淀粉样β斑块的吞噬作用，并使小胶质细胞极化从M1型转变为M2型。这些变化有助于减轻大脑中的炎症环境。这种创新方法可能为AD的无创、个性化治疗铺平道路，有可能改变神经退行性疾病的治疗策略。
