Turner Martin R
Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Brain. 2025 Nov 4;148(11):3783-3786. doi: 10.1093/brain/awaf276.
Turner highlights survivorship bias in the study of neurodegenerative disorders such as ALS, suggesting that meaningful progress may require a fundamental shift in focus from the affected to the resilient, and from what is seen to what is not. Neurodegeneration should be viewed as a loss of tolerance as much as a gain of toxicity.
特纳强调了肌萎缩侧索硬化症等神经退行性疾病研究中的幸存者偏差，指出有意义的进展可能需要从关注患者转向关注有恢复力的人，从关注已出现的情况转向关注未出现的情况，进行根本性的重点转移。神经退行性变应被视为耐受性的丧失，同样也是毒性的增加。
