van Oosten Monique, Johnsen Arni, Magnusson Bjorn, Gudjonsdottir Marta
Physiotherapy Monique slf, Mosfellsbaer, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Physiol Rep. 2025 Aug;13(15):e70490. doi: 10.14814/phy2.70490.
Dysfunctional breathing, characterized by inefficient ventilation, is common among asthmatic patients. It is mainly identified using questionnaires and by observing breathing patterns, but the actual efficiency of ventilation is rarely evaluated. This study aimed to compare ventilatory efficiency at rest between asthmatic patients and healthy subjects, and to assess the stability of these parameters over 1 year. Ventilation (V), respiratory rate (RR), tidal volume (V), carbon dioxide output (VCO) and end-tidal partial pressure (PCO), spirometry, and breath-holding time (BHT) were measured at baseline (M1) and 17-51 weeks later (M2). The ventilatory efficiency (V/VCO) and breathing pattern (RR/V) were calculated. Patients took the Asthma Control Test questionnaire (ACT). A mixed-design ANOVA at M1 showed that 30 not well-controlled asthmatic patients according to ACT (77% females, 7 with airway obstruction), and 23 matched healthy subjects had similar breathing parameters, except for BHT (p < 0.02) and PCO (p = 0.06). Only BHT changed, that is, it increased from M1 to M2 in the groups and remained shorter among the patients. Despite a shorter BHT among the patients, indicating a heightened perceptual sensitivity for dyspnoea, the ventilatory efficiency and breathing pattern at rest were similar and remained stable for 1 year in both groups.
功能失调性呼吸以通气效率低下为特征，在哮喘患者中很常见。它主要通过问卷和观察呼吸模式来识别，但通气的实际效率很少被评估。本研究旨在比较哮喘患者和健康受试者静息时的通气效率，并评估这些参数在1年中的稳定性。在基线时（M1）以及17 - 51周后（M2）测量通气量（V）、呼吸频率（RR）、潮气量（V）、二氧化碳排出量（VCO）和呼气末分压（PCO）、肺活量测定以及屏气时间（BHT）。计算通气效率（V/VCO）和呼吸模式（RR/V）。患者填写哮喘控制测试问卷（ACT）。M1时的混合设计方差分析显示，根据ACT有30名控制不佳的哮喘患者（77%为女性，7名有气道阻塞），以及23名匹配的健康受试者，除了BHT（p < 0.02）和PCO（p = 0.06）外，呼吸参数相似。只有BHT发生了变化，即两组中BHT从M1到M2均增加，且患者组的BHT仍较短。尽管患者的BHT较短，表明对呼吸困难的感知敏感性较高，但两组静息时的通气效率和呼吸模式相似且在1年中保持稳定。
