Deenstra Duco D, van Helvoort Hanneke A C, Djamin Remco S, van Zelst Cathelijne, In't Veen Johannes C C M, Antons Jeanine C, Spruit Martijn A, van 't Hul Alex J
Department of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Pulmonology, Catharina Hospital, Eindhoven, The Netherlands.
J Asthma. 2022 Aug;59(8):1560-1567. doi: 10.1080/02770903.2021.1959926. Epub 2021 Aug 6.
Asthma is frequently accompanied by dysfunctional breathing of which hyperventilation has been recognized as a subtype. The prevalence of hyperventilation in stable asthma has been scantily studied using blood gas analysis. Hence, a reliable estimate of its prevalence is lacking. It is unknown whether the Nijmegen Questionnaire (NQ) is a useful screening tool for hyperventilation in asthma. Therefore, the primary aim of this study was to determine the prevalence of hyperventilation in a large sample of patients with asthma in a stable state of disease. Secondary aims were to compare the clinical characteristics between patients with and without hyperventilation, and, to examine the concurrent validity of the NQ to detect hypocapnia in patients with asthma.
A real-world, observational, multicenter study was conducted. Capillary blood gas analysis was performed in adults with a confirmed diagnosis of stable asthma. A subset of patients completed the NQ.
A blood gas analysis was obtained in 1006 patients. In 17% of the patients an acute hyperventilation was found, and in another 23% a chronic hyperventilation was uncovered. Patients with a chronic hyperventilation blood gas were more often female, were younger and had a better spirometric outcomes. The NQ appeared not to correlate with PCO2.
Hyperventilation is common in patients with stable asthma. Chronic hyperventilation is more often found in females of younger age and with the best spirometric outcomes compared to patients without hyperventilation. The NQ is not a suitable screening tool for the presence of hyperventilation in stable asthmatics.
哮喘常伴有功能失调性呼吸，其中过度通气已被确认为一种亚型。关于稳定期哮喘患者中过度通气的患病率，此前利用血气分析进行的研究较少。因此，目前尚缺乏对其患病率的可靠估计。目前尚不清楚奈梅亨问卷（NQ）是否是哮喘患者过度通气的有效筛查工具。因此，本研究的主要目的是确定在一大群疾病处于稳定状态的哮喘患者中过度通气的患病率。次要目的是比较有和没有过度通气的患者的临床特征，并检验NQ在检测哮喘患者低碳酸血症方面的同时效度。
开展一项真实世界的观察性多中心研究。对确诊为稳定期哮喘的成年人进行毛细血管血气分析。一部分患者完成了NQ问卷。
共对1006例患者进行了血气分析。17%的患者存在急性过度通气，另有23%的患者发现有慢性过度通气。慢性过度通气血气患者中女性更多，年龄更小，肺功能检查结果更好。NQ似乎与二氧化碳分压不相关。
过度通气在稳定期哮喘患者中很常见。与无过度通气的患者相比，慢性过度通气在年龄较小、肺功能检查结果最佳的女性中更常见。NQ不是稳定期哮喘患者过度通气的合适筛查工具。
