Tariq Komel, Rana Nosheen Fatima, Javaid Sabah, Khadim Muneeba
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
SLAS Technol. 2025 Aug;33:100337. doi: 10.1016/j.slast.2025.100337. Epub 2025 Jul 28.
Implant-associated infections remain a significant challenge in orthopaedic and dental implants because they frequently result in implant failure, extended hospital stays, reoperations, and increased healthcare costs. Studies have shown that the cost of managing orthopaedic implant infections can range from USD 30,000 to over USD 100,000 per case, depending on severity and required surgical interventions. One of the primary pathogens responsible for these infections is Staphylococcus aureus, known for its potential to make biofilms on the surfaces of implants. To address this problem, this study investigates the formation of calcium phosphate-based biomimetic coatings substituted with calcium-doped ZnO nanoparticles on titanium discs to strengthen the antibacterial properties and enhance tissue integration. The SEM analysis of discs revealed uniform and dense coating layers with negligible surface defects, indicating a strong adhesive coating on titanium discs. The biomimetic-coated titanium implants with Ca-doped ZnO NPs were then evaluated for antibacterial activity using a closed system in an in vitro biofilm model. In case of 14 days treated disc, a significant increase in the antibacterial properties was observed against (Staphylococcus aureus, p < 0.0001). These findings suggest that calcium phosphate-based biomimetic coatings, doped with calcium-doped ZnO NPs show great potential for reducing the risk for implant-associated infections and improving the success rate of implants in clinical settings.
植入物相关感染在骨科和牙科植入物领域仍然是一项重大挑战，因为它们常常导致植入物失效、住院时间延长、再次手术以及医疗成本增加。研究表明，处理骨科植入物感染的成本每例可能从3万美元到超过10万美元不等，具体取决于感染的严重程度和所需的外科手术干预措施。导致这些感染的主要病原体之一是金黄色葡萄球菌，它以能够在植入物表面形成生物膜而闻名。为了解决这个问题，本研究调查了在钛盘上形成用钙掺杂的ZnO纳米颗粒替代的磷酸钙基仿生涂层，以增强抗菌性能并促进组织整合。对钛盘的扫描电子显微镜分析显示涂层均匀且致密，表面缺陷可忽略不计，这表明在钛盘上形成了牢固的附着涂层。然后，在体外生物膜模型的封闭系统中，对含有钙掺杂的ZnO纳米颗粒的仿生涂层钛植入物的抗菌活性进行了评估。对于经过14天处理的钛盘，观察到其对金黄色葡萄球菌的抗菌性能有显著提高（p < 0.0001）。这些研究结果表明，掺杂有钙掺杂的ZnO纳米颗粒的磷酸钙基仿生涂层在降低植入物相关感染风险以及提高临床环境中植入物成功率方面具有巨大潜力。
