Niijima Ryo, Kakizaki Takehiko, Park Chun-Ho, Kameshima Satoshi, Otaka Yuya, Kawaguchi Hiroaki
Kitasato University Veterinary Teaching Hospital, Aomori, Japan.
Laboratory of Veterinary Radiology and Radiation Biology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
J Vet Med Sci. 2025 Sep 5;87(9):1086-1091. doi: 10.1292/jvms.24-0517. Epub 2025 Jul 31.
Anticoagulants are commonly used to treat venous thrombosis. Rivaroxaban, a direct factor Xa inhibitor, is widely used in veterinary medicine to prevent and treat thromboembolism. It has been used to manage portal vein thrombosis (PVT) in humans. As the incidence of PVT with chronic hepatitis (CH) is low in dogs, treatment methods have not been fully established. This case report describes the treatment of a 9-year-old male American cocker spaniel with CH and ascites, possibly due to concurrent PVT, using rivaroxaban. During treatment with rivaroxaban and diuretics, the patient showed improvement in portal hypertension, ascites, and edema. Herein, we report the first case of using rivaroxaban for the management of PVT with CH (treated with glucocorticoids) in a dog.
抗凝剂常用于治疗静脉血栓形成。利伐沙班是一种直接的Xa因子抑制剂，在兽医学中广泛用于预防和治疗血栓栓塞。它已被用于治疗人类的门静脉血栓形成（PVT）。由于犬慢性肝炎（CH）并发PVT的发病率较低，治疗方法尚未完全确立。本病例报告描述了使用利伐沙班治疗一只9岁雄性美国可卡犬的CH和腹水，可能是由于并发PVT。在使用利伐沙班和利尿剂治疗期间，患者的门静脉高压、腹水和水肿有所改善。在此，我们报告首例在犬中使用利伐沙班治疗CH并发PVT（用糖皮质激素治疗）的病例。
