Lumbry Park Veterinary Specialists, Alton, UK (Calleja); Murdoch University, Perth, Western Australia (Shiel); Willows Veterinary Centre and Referral Service, Solihull, UK (Bree); Ryan Veterinary Hospital - PennVet, University of Pennsylvania, Philadelphia, Pennsylvania, USA (Silvestrini); North Downs Specialist Referrals, Bletchingley, UK (Trehy); Anderson Moores Veterinary Specialists, Winchester, UK (McMahon); University College Dublin, School of Veterinary Medicine, Dublin, Ireland (Murtagh).
Can Vet J. 2023 Feb;64(2):174-180.
The primary goals of this retrospective study were to describe a population of dogs with portal hypertension secondary to liver disease, and to assess whether prognosis could be inferred from historical, clinical, and clinicopathological data.
Dogs (N = 76) diagnosed with intrahepatic portal hypertension between 2011 and 2020 were included; dogs with known congenital hepatic anomalies were excluded. Effect on survival was assessed using univariable and multivariable Cox proportional hazards models for historical, clinical, and clinicopathological variables.
Dogs survived for a median of 14 d (range: 0 to 2028 d), with 31.6% being euthanized within 2 d of diagnosis and 23.7% surviving longer than 2 mo. Presence of jaundice and duration of clinical signs, expressed in days, were significantly associated with outcome in the univariable analysis (HR = 1.846, 95% CI: 1.094 to 3.117, = 0.02; HR = 0.995, 95% CI: 0.990 to 1.000, = 0.033, respectively). However, only presence of jaundice was significantly associated with increased hazard of death in the multivariable analysis.
Results of this study show that portal hypertension is associated with a poor prognosis; however, some dogs can show prolonged survival.
Clinical data can guide decision-making for clinicians and owners.
本回顾性研究的主要目的是描述一组因肝脏疾病导致门静脉高压的犬，并评估从病史、临床和临床病理数据中是否可以推断预后。
纳入 2011 年至 2020 年间诊断为肝内门静脉高压的犬（N=76）；排除已知先天性肝异常的犬。使用单变量和多变量 Cox 比例风险模型评估历史、临床和临床病理变量对生存的影响。
犬的中位生存时间为 14 d（范围：0 至 2028 d），31.6%在诊断后 2 d 内安乐死，23.7%存活时间超过 2 个月。黄疸的存在和临床症状的持续时间（以天为单位）在单变量分析中与预后显著相关（HR=1.846，95%CI：1.094 至 3.117，P=0.02；HR=0.995，95%CI：0.990 至 1.000，P=0.033）。然而，只有黄疸的存在在多变量分析中与死亡风险的增加显著相关。
本研究结果表明，门静脉高压与预后不良相关；然而，一些犬可以表现出延长的生存时间。
临床数据可以为临床医生和主人提供决策依据。
