Zhang Liyang, Wang Zehao, Wu Tongyang, Chen Xukun, Duan Huilian, Wang Di, Li Zhongxia, He Ruikun, Huang Guowei, Li Wen
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
BYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Asia Pac J Clin Nutr. 2025 Aug;34(4):619-626. doi: 10.6133/apjcn.202508_34(4).0013.
The incidence of hypertension is higher in individuals with the methylenetetra-hydrofolate reductase (MTHFR) 677TT genotype. Riboflavin serves as a coenzyme of MTHFR, but its role in hypertension prevalence is poorly understood. This study aimed to explore the relationship between riboflavin levels and hypertension and the impact of genotype on this relationship.
The case-control study used data from the Tianjin Elderly Nutrition and Cognition study, with 200 hypertensive patients and 200 matched non-hypertensive controls. It collected questionnaires, clinical data, and measured blood riboflavin levels using the dried blood spot technique. Conditional logistic regression analyzed varia-bles related to hypertension prevalence, with effects assessed by odds ratios (ORs) and 95% confidence intervals (CIs).
The hypertensive group had significantly lower riboflavin concentration than the non-hypertensive group (p<0.001). The regression analysis indicated that regardless of adjustment for sociodemographic characteristics, riboflavin concentration was negatively associated with the prevalence of hypertension. In the multivariable model, the OR was 0.607 [95%CI, 0.507-0.727], p<0.001. Additionally, we found an interaction between MTHFR genotype and riboflavin status. Compared with the combined TT genotype and below-median riboflavin levels as the reference category, the CC genotype and above-median riboflavin levels decreased the prevalence of hypertension (OR, 0.189 [95%CI, 0.071-0.501], p=0.001).
In conclusion, riboflavin status impacts the development of hypertension. There is also interaction between the MTHFR genotype and riboflavin. Specifically, low riboflavin status increases the prevalence of hypertension when combined with the MTHFR 677TT genotype.
亚甲基四氢叶酸还原酶（MTHFR）677TT基因型个体的高血压发病率较高。核黄素作为MTHFR的辅酶，但其在高血压患病率中的作用尚不清楚。本研究旨在探讨核黄素水平与高血压之间的关系以及基因型对这种关系的影响。
病例对照研究使用了天津老年人营养与认知研究的数据，包括200例高血压患者和200例匹配的非高血压对照。研究收集了问卷、临床数据，并采用干血斑技术测量血核黄素水平。采用条件逻辑回归分析与高血压患病率相关的变量，通过比值比（OR）和95%置信区间（CI）评估效应。
高血压组的核黄素浓度显著低于非高血压组（p<0.001）。回归分析表明，无论是否调整社会人口学特征，核黄素浓度与高血压患病率均呈负相关。在多变量模型中，OR为0.607 [95%CI，0.507 - 0.727]，p<0.001。此外，我们发现MTHFR基因型与核黄素状态之间存在相互作用。与TT基因型组合且核黄素水平低于中位数作为参考类别相比，CC基因型且核黄素水平高于中位数可降低高血压患病率（OR，0.189 [95%CI，0.071 - 0.501]，p = 0.001）。
总之，核黄素状态影响高血压的发生。MTHFR基因型与核黄素之间也存在相互作用。具体而言，低核黄素状态与MTHFR 677TT基因型组合时会增加高血压患病率。
