Nitric Oxide Innovations, LLC, United States.
Biochem Pharmacol. 2022 Dec;206:115325. doi: 10.1016/j.bcp.2022.115325. Epub 2022 Nov 5.
Hypertension remains a global health crisis. High blood pressure is the number one modifiable risk factor in the onset and progression of cardiovascular disease. Despite many different classes of drug therapies approved for hypertension, the use of polypharmacy and recommendations on lifestyle modification, many patients still suffer from uncontrolled or unmanaged hypertension. Nitric oxide is a naturally produced vasodilator that controls and regulates vascular tone and therefore controls and regulates blood pressure. Research over the past 40 years reveals that loss of nitric oxide production, termed endothelial dysfunction, is the earliest event in the development of hypertension. Strategies aimed at preventing the loss of nitric oxide production and/or therapeutic strategies designed to restore nitric oxide production will likely have a positive effect on patients' health and lead to better management of blood pressure. This review article will focus on the loss of nitric oxide production as the primary contributor to hypertension and also discuss safe and clinically proven strategies to restore nitric oxide production and recapitulate nitric oxide based signaling in humans.
高血压仍然是一个全球性的健康危机。高血压是心血管疾病发病和进展的头号可改变风险因素。尽管有许多不同类别的降压药物被批准用于高血压，但由于药物的联合使用以及生活方式改变的建议，许多患者仍然存在未得到控制或管理的高血压。一氧化氮是一种天然产生的血管扩张剂，可控制和调节血管张力，从而控制和调节血压。过去 40 年的研究表明，一氧化氮产生的丧失，即内皮功能障碍，是高血压发展的最早事件。旨在预防一氧化氮产生丧失的策略和/或旨在恢复一氧化氮产生的治疗策略可能对患者的健康产生积极影响，并导致更好的血压管理。本文综述将重点讨论一氧化氮产生的丧失作为高血压的主要原因，并讨论安全且经过临床验证的恢复一氧化氮产生和再现人类基于一氧化氮的信号转导的策略。
