2-甲基-5-硝基咪唑类化合物二甲硝唑、甲硝唑、塞克硝唑、奥硝唑、替硝唑、卡硝唑和帕硝唑对脆弱拟杆菌及脆弱拟杆菌群其他细菌的比较评价
Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group.
作者信息
Jokipii L, Jokipii A M
出版信息
Antimicrob Agents Chemother. 1985 Oct;28(4):561-4. doi: 10.1128/AAC.28.4.561.
Abstract
Tube-dilution MICs of seven 2-methyl-5-nitroimidazole compounds varying at the 1-substitution were determined against Bacteroides fragilis. Activities on a molar basis were ranked: tinidazole greater than panidazole greater than ornidazole greater than metronidazole greater than or equal to secnidazole greater than carnidazole greater than dimetridazole. Geometric mean MICs varied from 0.5 to 6.6 microM, and MICs against individual strains varied up to 50-fold between compounds. In general, the MIC of each drug correlated with that of each of the other drugs, but with tinidazole the correlation coefficients tended to be small and were not significant versus metronidazole and secnidazole. MICs against 14 other bacteria of the B. fragilis group, including B. distasonis, B. ovatus, B. thetaiotaomicron, B. uniformis, and B. vulgatus, were within the range determined for B. fragilis.
摘要
测定了7种在1-取代基上有所不同的2-甲基-5-硝基咪唑化合物对脆弱拟杆菌的试管稀释最低抑菌浓度（MIC）。按摩尔活性排序为：替硝唑＞帕硝唑＞奥硝唑＞甲硝唑≥塞克硝唑＞卡硝唑＞地美硝唑。几何平均MIC在0.5至6.6微摩尔之间变化，不同化合物对各菌株的MIC差异高达50倍。总体而言，每种药物的MIC与其他每种药物的MIC相关，但替硝唑的相关系数往往较小，与甲硝唑和塞克硝唑相比无统计学意义。对脆弱拟杆菌属的其他14种细菌，包括解脲拟杆菌、卵形拟杆菌、多形拟杆菌、单形拟杆菌和普通拟杆菌的MIC，均在针对脆弱拟杆菌测定的范围内。
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