Meng Chen, Feng Siyuan, Hao Zikai, Liu Hong
Beijing Institute of Otolaryngology, Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Institute of Environmental Biology and Life Support Technology, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
NPJ Biofilms Microbiomes. 2025 Jul 30;11(1):147. doi: 10.1038/s41522-025-00779-7.
Strains of Roseburia inulinivorans, Bacteroides uniformis, and Eubacterium rectale have exhibited multi-pathway therapeutic efficacy against anxiety and depression-like behaviors in chronic unpredictable mild stress (CUMS) rats. However, the combined therapeutic effects of these strains remain to be elucidated. Behavioral tests showed that a mixture of these strains reduced anxiety and depression-like behaviors. 16S rRNA sequencing revealed that the mixtures decrease the relative abundance of potentially pathogenic bacteria within the gut microbiota. Furthermore, the mixture increased the levels of butyric, isobutyric, and isovaleric acids in the gut and decreased pro-inflammatory factors in serum. It also lowered diamine oxidase, histamine in brain tissue, increased DL-kynurenine, and reduced cortisol secretion by the hypothalamic pituitary adrenal axis. In summary, the mixture significantly alleviated anxiety and depression-like behaviors.
菊糖罗斯拜瑞氏菌、单形拟杆菌和直肠真杆菌菌株已在慢性不可预测轻度应激（CUMS）大鼠中表现出针对焦虑和抑郁样行为的多途径治疗功效。然而，这些菌株的联合治疗效果仍有待阐明。行为测试表明，这些菌株的混合物可减少焦虑和抑郁样行为。16S rRNA测序显示，该混合物降低了肠道微生物群中潜在致病菌的相对丰度。此外，该混合物提高了肠道中丁酸、异丁酸和异戊酸的水平，并降低了血清中的促炎因子。它还降低了脑组织中的二胺氧化酶、组胺，增加了DL-犬尿氨酸，并减少了下丘脑-垂体-肾上腺轴的皮质醇分泌。总之，该混合物显著减轻了焦虑和抑郁样行为。
